Biographical Memoirs Volume 90 (2009) / Chapter Skim
Currently Skimming:
MALCOLM ROBERT IRWIN
MALCOLM ROBERT IRWIN
Pages 198-211
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 199... ...
Second, he reasoned that antibodies provide tools for defining antigens segregating as inherited variations within and among species. His assumed one gene-one antigen concept developed insight into evolutionary relationships difficult to assess in other ways.
|
From page 200... ...
On graduating from Iowa State and faced with uncertainty of what career path to follow, he chose to spend three years at the American Farm School at Salonika in Greece. That experience stimulated thoughts of using scientific procedures to improve farm animals and plants.
|
From page 201... ...
W Lindstrom, who was later to influence young Bob Irwin at Iowa State, had joined Cole at Wisconsin in 1919 but left for Iowa State in 1922, the year R
|
From page 202... ...
Irwin saw these populations as ideal for his goal of using antibody reagents to identify inherited antigens on blood cells as an approach to understanding the genetic basis of species relationships in evolution. The first set of a long series of papers was published in 1936, and achieved wide recognition.
|
From page 203... ...
Irwin received the Daniel Girard Elliot Medal of the National Academy of Sciences in recognition of that work. The idea that the cellular antigens were closely related to their corresponding genes was based mainly on the absence of gene interaction in their appearance; one gene-one antigen was the rule.
|
From page 204... ...
Stormont, Irwin published in the 1942 Journal of Immunology the definitive follow-up of the initial publication on the immunogenetics of cattle blood cell antigens. Two dairy cattle breed associations, the Holstein-Friesian Association and the American Guernsey Cattle Club, saw very practical uses for this work.
|
From page 205... ...
When I took up postdoctoral work in the laboratory in 1941, it was the cattle program I joined, with Stormont as my mentor. We provided paid services to the breed associations, and in the process collected a great deal of information from the blood samples they shipped to us, often including whole herds and large families of cattle, ideal for our basic genetic and immunological studies.
|
From page 206... ...
; his daughter, Harriet Anne; his son, Joseph Robert; and four grandchildren. When Bob Irwin was elected to the National Academy of Sciences, there was no Genetics Section.
|
From page 207... ...
8. Washington, D.C.: National Academy Press, 1995.
|
From page 208... ...
Immunogenetic studies of spe cies and of species hybrids in pigeons, and the separation of species-specific characters in backcross generations.
|
From page 209... ...
Immunogenetic studies of species: Segrega tion of serum components in backcross individuals. Genetics 27(2)
|
From page 210... ...
Palm. Interaction of nonallelic genes on cellular antigens in species hybrids of Columbidae.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.