Biographical Memoirs Volume 90 (2009) / Chapter Skim
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GERALD DONALD AURBACH
GERALD DONALD AURBACH
Pages 2-15
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After graduation from medical school, Gerry took an internship at the New England Medical
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Despite his early success Gerry felt he needed further training in research and applied to a new, prestigious training program at the National Institutes of Health in Bethesda, Maryland. Gerry was selected for the Research Associate Training Program and in 1959 joined the laboratory of William Jakoby, where he received training in enzyme biochemistry.
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Fuller Albright had described pseudohypoparathyroidism as the first example of a disease of hormone resistance rather than hormone deficiency. Gerry and Lew Chase discovered that patients with pseudohypoparathyroidism failed to elevate cyclic AMP levels in the urine in response to parathyroid hormone and showed that the biochemical basis of this was a defect in the ability of parathyroid hormone to activate renal adenylate
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This compound was used as a marker of specific binding to the beta-adrenergic receptor, and enabled Aurbach and colleagues to study in detail a critical initial step in hormone action. Gerry was a fine physician and his groundbreaking research in the parathyroid hormone field resulted in many patients being referred to the National Institutes of Health from community hospitals as well as large medical centers in the United States and abroad.
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Neuman Award of the American Society for Bone and Mineral Research in 1981, the Gairdner Foundation International Award in 1983, the Edwin B Astwood Award from the Endocrine Society in 1985; and the Distinguished Service Medal of the Public Health Service in 1988.
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Gerry was a member of many prestigious medical societies, including the American Society for Clinical Investigation, the American Society for Biochemistry and Molecular Biology, and the Association of American Physicians. He was a founding member of the American Society for Bone and Mineral Research.
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I met Gerry in Boston when he was a fellow in the laboratory of Ted Astwood and I was a medical student. We came to the National Institutes of Health the same year and were both interested in the mechanism of action of polypeptide hormones.
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T Potts Jr.
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T Potts Jr.
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T Potts Jr.
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T Potts Jr.
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Marx. Clonality of parathyroid tumors in familial multiple endocrine neoplasia type I
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G erald donald aurbach 15
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