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Appendix F: Food Safety Research at Intramural and Extramural U.S. Food and Drug Administration Research Centers, by Topic
Pages 493-504

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From page 493...
... Additives Development of Methodology to Detect and Quantitate Intermediates and Unsulfonated Impurities in Certifiable Color Additives Use of Migration Models for Indirect Food Additive Approval Allergens Approaches to Establish Thresholds for Major Food Allergens and for Gluten in Food The Detection of Food Allergens Using Rapid Immunology– Based Detection Devices Direct Detection, Confirmation, and Measurement of Allergens in Food Matrices Effects of Cleaning on Removal of Allergenic Foods from Food-Contact Surfaces Food Allergen Research Prevalence of Self-Reported Food Allergy in American Adults and Use of Food Labels Filth and Spoilage Assessment of Seafood Decomposition with Electronic Sensors Evaluation of the 2-Day Hydrophobic Grid Membrane Filter, Simplate Yeast and Mold Color Indicator, and Petrifilm Dry Dehydratable Film Methods for the Enumeration of Fungi from Foods Filth and Extraneous Materials in Foods continued 
From page 494...
... Microarray Technology in Bacterial Identification Using Different Food Matrices and the Detection of DNA Hybridization Constructs Using Infrared Spectroscopy The Application of Interferometric Biosensor Technology to the Analysis of Food Matrices for Multiple Bacterial and Viral Pathogens, Allergens, and Toxins Characterization of the Zinc-Containing Metalloprotease Encoded by zpx and Development of a Species-Specific Detection Method for Enterobacter sakazakii Development and Validation of Methods for Species Identification of Potentially Hazardous Fish Species Based on DNA Bar-Coding Development of Liquid Chromatography/Mass Spectrometry Protein Profiling as a Tool for Bacterial Differentiation Diagnostic Methodology for Foodborne Illness (Bacteria and Virus) Evaluation of Bioluminex Test Methods and Application to the Analysis of Foods Evaluation of Direct Analysis in Real Time Ionization and Application to the Analysis of Foods and Food Contact Substances Infrared Detection of Label-Free DNA Hybridization on a Microarray Platform for Use in the Identification of Virulence Genes in Foodborne Microorganisms Molecular Applications for Identifying Microbial Pathogens in the Post-9/11 Era
From page 495...
... for Identification and Classification of Foodborne Bacteria and Spores Foodborne Pathogens: Genomic Analysis of Cyclopsora cayetenensis and Emerging Pathogens Cryptosporidium spp: Methods Development for Viability and Molecular Epidemiological Applications Identification and Analyses of Invasion Gene Targets for Use as Diagnostic Probes to Detect Virulent Enterobacter sakazakii Molecular Characterization of Foodborne Pathogens and the Development of Virulence Factor Foodborne Pathogens: Effects of Food Processing on Viruses in Foods Foodborne Viruses Microarray Based Identification of Foodborne Viruses Viral Survival During Produce Processing and Storage: Determined by Cellar Infectivity and Real-Time Polymerase Chain Reaction (PCR) Foodborne Pathogens: Development of a Method to Enrich and Detect Salmonella Gram-Negative Bacterial enteritidis in Whole Eggs Pathogens (E.
From page 496...
... /Health Canada Public Health Risk Assessment of Listeria monocytogenes in Cheese Risk Assessment for the Public Health Impact of Highly Pathogenic Avian Influenza Virus in Poultry Meat, Shell Eggs, and Egg Products Risk Assessment to Determine Potential of Chronic Wasting Disease in Infected Cervids as a Human Health Risk Foodborne Pathogens: Biomarkers of Neurotoxic Shellfish Poisoning Seafood Toxins Ciguatera Fish Poisoning Detection Methods for Paralytic Shellfish Poisoning Toxins Development of Conjugates of Saxitoxins for the Production of Antibodies An Intervention Analysis for the Reduction of Exposure to Methylmercury from the Consumption of Seafood by Women of Child-Bearing Age Mussel-Associated Azaspiracid Intoxication in the United States Neurotoxic Shellfish Poisoning Non-Traditional Vectors for Paralytic Shellfish Poisoning
From page 497...
...  APPENDIX F TABLE F-1 Continued Topic Project Paralytic Shellfish Poisoning: Link Between Surface Algal Blooms and Deep Water Shellfish Toxicity in Federal Waters Foodborne Pathogens: Indicator Microorganisms and Viruses in Shellfish in Harvest Surveys Waters Microbiological Survey of Raw Oysters Collected at Retail Across the United States Survey of U.S. Raw Milk Supply for Pathogens Toxicology: Detection Analysis of Total Mercury in Foods by Compton Suppression Instrumental Neutron Activation Analysis Determination of the Thyroid-Interactive Anions Iodide, Perchlorate, and Thiocyanate in Food Development of Tuna Reference Material for Toxic Elements Impact of Processing on Detection of Melamine and Cyanuric Acid Methodology for Determination of Volatile Contaminants in Foods Two-Dimensional Gas Chromatography and Time-of-Flight Mass Spectrometry for the Determination of Pesticides and Persistent Organic Pollutants in Foods Validating the Predictive Performance of Caenorhabditis elegans as an Animal Model for Toxicity Testing Toxicology: Mechanisms Cellular and Cytokine Biomarkers for Infectious and Inflammatory Models Denaturation/Renaturation Kinetics of Staphylococcal Enterotoxin in Acidic Foods Evaluation of the Mass Transfer Properties of Perfluoro Chemicals from Paper Food Packaging Hepatotoxicity -- Role of Gender, Species and Inflammation on In Vitro and In Vivo Biomarkers of Liver Toxicity Interaction of Combined Exposure to the Microbial Toxin Lipopolysaccharide (and Deficient or Graded Dietary Vitamin D Level Toxicology: Monitoring Acrylamide Testing at CFSAN: Exploratory Survey Results Aquaculture Drugs and Chemicals FDA Toxicity Databases and Real-Time Data Entry FDA's Total Diet Study: Dietary Intake of Perchlorate and Iodine Health Care Provider Survey -- re the Methylmercury Advisory continued
From page 498...
... Develop Needed Enforcement Methods for Drug Residues Evaluate Screening Test Performance Perform Method Trials to Determine Drug Residues from Unapproved Uses Use Tissue-Fluid Correlations to Predict Drug Residue Levels in Edible Tissues from Food-Producing Animals Premarket Drug Review: The Clonal Spread of Multidrug-Resistant Non-Typhi Antimicrobial Resistance Salmonella Serotypes Mechanisms Determine Microbial Ecology of Antibiotic Resistance Development and Dissemination in the Food Animal Production Environment Genetic Diversity and Antimicrobial Susceptibility Profiles Among Staphylococcus aureus Isolated from Bovine Mastitis Interrogate Salmonella Diversity Using a Novel 35 Genome Salmonella Species Microarray -- A Critical Path Study Use Molecular and Biochemical Methods to Determine the Animal Origin of Foodborne Bacterial Pathogens Premarket Drug Review: Broth Microdilution Susceptibility Testing of Campylobacter Microbiological Methods jejuni and the Determination of Quality Control Ranges for 14 Antimicrobial Agents Conduct Molecular Characterization of Foodborne Bacterial Pathogens Isolated from Animals and Retail Meats by Microarray Technology Develop Antimicrobial Susceptibility Testing Methods and Interpretive Criteria for Aquatic Animal Microflora Develop Standardized In Vitro Antimicrobial Susceptibility Testing Methods for Bacterial Pathogens Salmonella Resistant to Extended-Spectrum Cephalosporins: Prevalence and Epidemiology
From page 499...
... Participation in the and Monitoring: Survey NARMS Program Programs CVM Participation in PulseNet Targeted Surveys as Needed Veterinary Drug Residues National Center for Toxicological Research (NCTR) Antimicrobial Resistance Antimicrobial Resistance Genetics of "Emerging" Salmonella enterica Serovar Javiana Phenotypes Involved in Clinical and Food-Related Outbreaks Beta-Lactamase Resistance in enterococci Heteroresistance to Vancomycin and Novel Point Mutations in Tn1546 of Enterococcus faecium ATCC 51559 Molecular Characterization of Multidrug-Resistant Enterococcus spp from Poultry and Dairy Farms: Detection of Virulence and Vancomycin Resistance Gene Markers by PCR Substitutions of Amino Acids in Alpha-Helix-4 of Gyrase A Confer Fluoroquinolone Resistance on Clostridium perfringens continued
From page 500...
... 00 ENHANCING FOOD SAFETY TABLE F-1 Continued Topic Project Methods Development Biostatistical Modeling for Food Protection Plan Development of Public Toxicogenomics Software for Microarray Data Management and Analysis Evaluation of Certain Food Additives and Contaminants Genotoxic Effects of Acrylamide and Glycidamide in Mouse Lymphoma Cells In Vitro Antimicrobial Susceptibility, Genetic Diversity and Prevalence of Uridine Diphosphate-Glucose 4-Epimerase Gene in Campylobacter coli and Campylobacter jejuni from Turkey Production Facilities Innovative, Static, and Dynamic Chemical Sensors for Food Safety -- Litmus Cooperative Research and Development Agreement Integrating Time-Course Microarray Gene Expression Profiles with Cytotoxicity for Identification of Biomarkers in Primary Rat Hepatocytes Exposed to Cadmium Isolation and Characterization of Tetracycline-Resistant Citrobacter spp from Catfish Mold2, Molecular Descriptors from Two-Dimensional Structures for Chemoinformatics and Toxicoinformatics Molecular Characterization of Salmonella spp and Vibrio spp Isolated from Seafood and Development of Microarray Detection Method Molecular Typing Methodologies for Microbial Source Tracking and Epidemiological Investigations of Gram Negative Bacterial Foodborne Pathogens Physiologically-Based Pharmacokinetic/Pharmacodynamic Model for Acrylamide and Its Metabolites in Mice, Rats, and Humans Rapid Bacterial Identification with Subspecies-Level Specificity Real-Time PCR Assays for Ricin and Related Potential Bioterrorism Agents in Foods The Survivability of Bacillus anthracis (Sterne Strain) in Processed Liquid Eggs Other Chemical Inactivation of Protein Toxins on Food Contact Surfaces Effect of Egg White Addition to Milk and Ground Beef on the Survival of Sterne Strain of Bacillus anthracis, Salmonella enterococci, and Staphylococci at Different Temperatures Laboratory Studies in Melamine and Cyanuric Acid Biochemical Toxicology Mechanistic Evaluation of the Induction of Lymphoproliferation and Apoptosis Inhibition by Probiotic Bacteria in Mice Infected with Salmonella enterica
From page 501...
... Food Science and Liquid Chromatographic Analysis of Vitamin B6 in Technology Reconstituted Infant Formula: Collaborative Study Potential Use of DNA Barcodes in Regulatory Science: Applications of the Regulatory Fish Encyclopedia Foodborne Pathogens: Molecular Confirmation of Oyster as the Vector for General Hepatitis A in a 2005 Multistate Outbreak Recovery of Mycobacterium bois from Soft Fresh Cheese Originating in Mexico Foodborne Pathogens: Comparison of Salmonella enterica Serovar Heidelberg Gram-Negative Susceptibility Testing Results Bacterial Pathogens (Campylobacter, E coli, Salmonella, Shigella, Yersina)
From page 502...
... Reducing and Controlling Salmonella and E coli in Crops Role of Efflux Pumps and Topoisomerase Mutations in Fluoroquinolone Resistance in Campylobacter jejuni and Campylobacter coli Foodborne Pathogens: Survival of Enterobacter sakazakii in a Dehydrated Powdered Processing Infant Formula Risk-Based Research Emotion Regarding a Food Crisis and Predicting Consumers' Hesitancy to Eat the Food After the Crisis Evaluation of the ALERT (Assure, Look, Employees, Reports, Threat)
From page 503...
... Food Safety Risks and Mitigation Strategies for Feral Swine (Sus scrofa) Near Agriculture Fields Foodborne Pathogens: Escherichia coli O157:H7 in Feral Swine Near Spinach Fields Gram-Negative Bacterial and Cattle, Central California Coast Pathogens (E.
From page 504...
... coli, Effect of Wilting and Tissue Infiltration on the Behavior of Salmonella, Shigella, E coli O157:H7 on Leaf Lettuce Directly After Harvest Yersina)


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