Guide for the Care and Use of Laboratory Animals Eighth Edition (2011) / Chapter Skim
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The Guide is created by scientists and veterinarians for scientists and veterinarians to uphold the scientific rigor and integrity of biomedical research with laboratory animals as expected by their colleagues and society at large. The Guide plays an important role in decision making regarding the use of vertebrate laboratory animals because it establishes the minimum ethical, practice, and care standards for researchers and their institutions.
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used in research, but establishes general principles and ethical considerations that are also applicable to these species and situations. References provide the reader with additional resources, and supplemental information on breeding, care, management, and use of selected laboratory animal species is avail Animal use: The proper care, able in other publications prepared use, and humane treatment of by the Institute for Laboratory Animal laboratory animals produced for Research (ILAR)
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of the Guide useful for their interactions with the IACUC, attending veterinarian, and administrators regarding animal care as well as the preparation of animal care and use protocols. Scientific review committees and journal editors may choose to refer to multiple sections of the Guide to determine whether scientists contributing proposals and manuscripts have met the appropriate standards in their planned use of animals.
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. Finally, members of the public should feel assured that adherence to the Guide will ensure humane care and use of laboratory animals.
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Principal investigators are strongly discouraged from advocating animal reuse as a reduction strategy, and reduction should not be a rationale for reusing an animal or animals that have already undergone experimental procedures especially if the well-being of the animals would be compromised. Studies that may result in severe or chronic pain or significant alterations in the animals' ability to maintain normal physiology, or adequately respond to stressors, should include descriptions of appropriate humane endpoints or provide science-based justification for not using a particular, commonly accepted humane endpoint.
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Performance standard means a standard or guideline that, while describing a desired outcome, provides flexibility in achieving this outcome by granting discretion to those responsible for managing the animal care and use program, the researcher, and the IACUC. The performance approach requires professional input, sound judgment, and a team approach to achieve specific goals.
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For topics on which information is insufficient or incomplete, sustained research into improved methods of laboratory animal management, care, and use is needed for the continued evaluation and improvement of performance and engineering standards. Practice standard means the application of professional judgment by qualified, experienced individuals to a task or process over time, an approach that has been demonstrated to benefit or enhance animal care and use.
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2007. Memorandum of Understanding Between the Office of Laboratory Animal Welfare, National Institutes of Health, US Department of Health and Human Services and the Office of Research Oversight and the Office of Research and De velopment, Veterans Health Administration, US Department of Veterans Affairs Concerning Laboratory Animal Welfare.
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2002. Public Health Service Policy on Humane Care and Use of Laboratory Animals.
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