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Dietary Reference Intakes for Calcium and Vitamin D (2011) / Chapter Skim
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Appendix G: Cases Studies of Vitamin D Toxicity
Pages 1025-1034

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From page 1025...
... G Cases Studies of Vitamin D Toxicity 1025
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From page 1026...
... ; 3 tsp Lancet letter to the editor 1947. BMJ letter to Not specified Cod liver oil editor Ross.
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From page 1027...
... Tx with Ca-free dialysate failed to reduce serum Ca; prednisolone for 7 d; calcitonin tx stabilized serum Ca 17 mg/dL Nausea and non-tender lumps over both tibias; X-rays showed alternating patterns of increased and decreased bone density. Loss of bone density and tissue calcification continued despite removal of vitamin D and the pt died 14.4 mg/dL 470 ng/ml Constipation and colic; persistent hypertension; no renal, cardiac, neurological symptoms noted.
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From page 1028...
... 1979. 49-yr-old female Vitamin D: 100,000 3.8 yr Arch Intern Med post-thyroidectomy units/d; plus high 139:974-977 calcium diet Sterling and 69-yr-old male with Vitamin D (Calciferol)
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From page 1029...
... Removal of vitamin D and tx mg/dL) with corticosteroids resolved elevated calcium and CV abnormality 14.3 mg/dL Weight loss, memory loss; evidence of renal damage and corneal calcification.
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From page 1030...
... 1995. 10 family members Cholecalciferol Unknown exposure Ann Intern Med and 1 servant; concentrate in peanut oil 122:511-513 age range 8-69 = 2 million U/g yr ingested oil containing a veterinary vitamin D concentrate
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From page 1031...
... D. No association was found 2.3 39.5 between milk intake and elevated serum calcium; 2.4 41.3 there was an association with elevated serum 25(OH)
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From page 1032...
... 1979. 3 family members; Cholecalciferol Single exposure Postgrad Med J 2 adults ages 24 yr concentrate in nut oil = 5 55:897-902 and 1 infant aged million IU/ml 11 mo Chiricone et al.
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From page 1033...
... (469.2 ng/ml) nausea, vomiting; tx with IV saline, furosemide, and pamidronate 3.95 mmol/L 58–60 IU/ml Both adults developed renal failure.
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Key Terms

  • cod liver
  • bmj letter
  • bone resorption
  • bone density
  • internal med

  • serum calcium
  • stabilized serum
  • arch intern
  • reported feeling
  • daily rizzoli

  • corticosteroids resolved
  • weeks prac
  • calcification continued
  • continued despite
  • ann internal

  • intern med
  • weeks editor
  • reduce serum
  • inhibit bone
  • toxic dose

  • dose varies
  • infants ages
  • dis child
  • continued intake
  • arch dis

  • neurological symptoms
  • pts reported
  • irradited ergosterol
  • despite removal
  • memory loss


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