Dietary Reference Intakes for Calcium and Vitamin D (2011) / Chapter Skim
Currently Skimming:
9 Information Gaps and Research Needs
9 Information Gaps and Research Needs
Pages 513-522
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 513... ...
Although the uncertainties surrounding the DRIs have been described in this report and the scientific judgments made are documented, evidence from future research designed to overcome the limitations encountered by this committee can improve the ability to determine reference values in the future. Although the committee's discussions form the basis for the identification of these research needs, other sources of research needs were noted, for example the National Institutes of Health Roundtable on Vitamin D Research Needs (Brannon et al., 2008)
|
From page 514... ...
514 FIGURE 9-1 General nature of information gaps within the evidence base for calcium and vitamin D DRI development as related to risk assessment steps. NOTE: 25OHD = serum 25-hydroxyvitamin D
|
From page 515... ...
Methodology Step 2: "Hazard Characterization" or Intake-Response Assessment and Specification of DRIs Dose–Response 1. Conduct studies to identify specific health outcomes in relation Relationship to graded and fully measured intakes of calcium and of vitamin D
|
From page 516... ...
Clarify threshold effects of calcium and vitamin D on skeletal health outcomes by life stage and for different racial/ethnic
|
From page 517... ...
3. Explore causal role for vitamin D in non-skeletal health outcomes.
|
From page 518... ...
Understanding the distribution, storage, and mobilization of 25OHD in body pools would enhance the understanding regarding relationships among exposure to vitamin D from intake or endogenous synthesis, circulation serum levels of 25OHD, and health outcomes. The role of storage com partments and factors important to the mobilization of vitamin D is noticeably lacking.
|
From page 519... ...
In order to ensure the most objective and comprehensive systematic evidence reviews in the future, approaches to better weight poten tial health outcomes are needed. STEP 2: "HAZARD CHARACTERIZATION" OR INTAKE RESPONSE ASSESSMENT AND SPECIFICATION OF DIETARY REFERENCE INTAKES The committee encountered major challenges in determining the dose–response relationships for calcium and vitamin D
|
From page 520... ...
radiation exposure relative to skin cancer exists that also enables vitamin D production. Whether a minimal or threshold UVB exposure level is possible to both enable subcutaneous vitamin D synthesis and avoid risk of skin cancer needs to be examined.
|
From page 521... ...
However, as noted in Chapter 8, the cut-point levels of serum 25OHD intended to specify deficiency and sufficiency for the purposes of interpreting laboratory analyses and for use in clinical practice have been subject to a wide variation in specification without a systematic, evidence-based consensus development process. The importance of this specification to both the well-being of the North American population and to ensuring that the population is confident in their health and nutriture results in the committee calling attention to this research need.
|
From page 522... ...
, there is a need for more and better data related to the relatively unstudied life stage groups of children and young adults and the differences among racial/ethnic groups. Furthermore, the committee found a pressing public health need for development of consensus, sciencebased guidelines to establish cut-point levels for vitamin D deficiency and insufficiency.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.