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Appendix F: Expert Guidance for Chapter 4: Standards for Synthesizing the Body of Evidence
Pages 281-290

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From page 281...
... F Expert Guidance for Chapter 4: Standards for Synthesizing the Body of Evidence 281
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From page 282...
... Centre for Reviews and Standards and Elements Effective Health Care Program Dissemination (CRD) The Cochrane Collaboration 4.1 Use a prespecified The AHRQ method for The planned approach to Adopts the GRADE system for method to evaluate the evaluating the body of evaluating the body of evaluating the body of evidence.
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From page 283...
... Provides guidance on some elements (see below)
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From page 284...
... 4.2.2 Describe the Assess and document decisions Recording the strengths and Whether the synthesis is strengths and limitations on "quality" and applicability weaknesses of included studies quantitative or qualitative, of individual studies and of individual studies, including provides an indication of methodological limitations are patterns across studies criteria for overall quality whether the results have been described in detail through assessment. unduly influenced by aspects presentation of risk of bias tables, of study design or conduct.
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From page 285...
... The choice of metathe systemic review will meaningful answer to a well- the outset of the review. analysis method should be stated, include a quantitative formulated research question.
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From page 286...
... or have access to, expertise in execute, and peer review the expertise. A peer reviewer with The team may wish to seek systematic review methodology meta-analyses statistical expertise should be advice from methodological (including statistical expertise)
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From page 287...
... A statistical test for heterogeneity using subgroup examination of the forest plot, heterogeneity is available, but a analysis or meta-regression or tested using chi square test or useful statistic for quantifying sensitivity analyses. Q statistic, quantified using the inconsistency is I2.
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From page 288...
... 2010. AHRQ series paper 5: Grading the strength of a body of evidence when comparing medical interventions: AHRQ and the Effective Health Care Program.
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From page 289...
... 2010. AHRQ series paper 3: Identifying, selecting, and refining topics for comparative effectiveness systematic reviews: AHRQ and the Effective Health Care Program.
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Key Terms

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  • comparative effectiveness
  • methods guide

  • accessed january
  • systematic reviews
  • clinical epidemiology
  • narrative synthesis
  • statistical expertise

  • cochrane collaboration
  • review team
  • following characteristics
  • study design
  • sensitivity analyses

  • confidence intervals
  • heterogeneity using
  • square test
  • methodological limitations
  • sensitivity analysis

  • julian higgins
  • combined estimate
  • evidence using
  • clinical summarize
  • peer reviewer


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