Acute Exposure Guideline Levels for Selected Airborne Chemicals Volume 10 (2011) / Chapter Skim
Currently Skimming:
Pages 227-249
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 227... ...
5 Phosphorus Oxychloride1 Acute Exposure Guideline Levels PREFACE Under the authority of the Federal Advisory Committee Act (FACA)
|
From page 228... ...
228 Acute Exposure Guideline Levels sensory effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure.
|
From page 229... ...
Phosphorus Oxychloride 229 described also resulted in lethality. No information was available on reproductive and developmental toxicity, genotoxicity, or carcinogenicity.
|
From page 230... ...
230 Acute Exposure Guideline Levels 1. INTRODUCTION Phosphorus oxychloride is a colorless, clear, fuming liquid with a musty, pungent odor.
|
From page 231... ...
Phosphorus Oxychloride 231 2.
|
From page 232... ...
232 Acute Exposure Guideline Levels A health hazard evaluation conducted by the National Institute of Occupational Safety and Health (NIOSH) of the FMC Corporation plant in Nitro, West Virginia, reported that workers with known repeated exposures to phosphorus oxychloride or phosphorus trichloride experienced a significantly higher (p < 0.001)
|
From page 233... ...
Phosphorus Oxychloride 233 2.4. Genotoxicity No human genotoxicity data on phosphorus oxychloride were found.
|
From page 234... ...
234 Acute Exposure Guideline Levels with influent air before being pumped into the chamber. Test article concentrations were determined by collection and weighing of material on a filter.
|
From page 235... ...
Phosphorus Oxychloride 235 3.1.2. Guinea pigs Weeks et al.
|
From page 236... ...
236 Acute Exposure Guideline Levels 3.5. Carcinogenicity No animal data were found regarding the carcinogenic potential of phosphorus oxychloride.
|
From page 237... ...
Phosphorus Oxychloride 237 4.2. Mechanism of Toxicity The precise mechanism of toxicity of inhaled phosphorus oxychloride has not been elucidated.
|
From page 238... ...
238 Acute Exposure Guideline Levels 4.4. Other Relevant Information 4.4.1.
|
From page 239... ...
Phosphorus Oxychloride 239 6.
|
From page 240... ...
240 Acute Exposure Guideline Levels 7.2. Summary of Animal Data Relevant to AEGL-3 Lethality data are based on 4-h LC50 values for rats and guinea pigs.
|
From page 241... ...
Phosphorus Oxychloride 241 (1954) , where repeated exposures to concentrations up to 3.2 ppm resulted in irritation and minor respiratory difficulties but not death.
|
From page 242... ...
242 Acute Exposure Guideline Levels TABLE 5-6 AEGL-3 Values for Phosphorus Oxychloride 10 min 30 min 1h 4h 8h 1.1 ppm 1.1 ppm 0.85 ppm 0.54 ppm 0.27 ppm TABLE 5-7 Standards and Guidelines for Phosphorus Oxychloride Exposure Duration Guideline 10 min 30 min 1h 4h 8h AEGL-1 Not recommended AEGL-2 Not recommended AEGL-3 1.1 ppm 1.1 ppm 0.85 ppm 0.54 ppm 0.27 ppm a TLV-TWA (ACGIH)
|
From page 243... ...
Phosphorus Oxychloride 243 ACGIH (American Conference of Governmental Hygienists)
|
From page 244... ...
244 Acute Exposure Guideline Levels NRC (National Research Council)
|
From page 245... ...
Phosphorus Oxychloride 245 APPENDIX A DERIVATION OF AEGL VALUES FOR PHOSPHORUS OXYCHLORIDE Derivation of AEGL-1 AEGL-1 values are not recommended because insufficient data. Absence of AEGL-1 values does not imply that exposure below the AEGL-3 values are without adverse effects.
|
From page 246... ...
246 Acute Exposure Guideline Levels 4-h AEGL-3 C3 × 4 h = 16,693.12 ppm-h C = 16.1 ppm 4-h AEGL-3 = 16.1 ppm/30 = 0.54 ppm 8-h AEGL-3 C1 × 8 h = 64.4 ppm-h C = 8.05 ppm 8-h AEGL-3 = 8.05 ppm/30 = 0.27 ppm
|
From page 247... ...
Phosphorus Oxychloride 247 APPENDIX B ACUTE EXPOSURE GUIDELINES FOR PHOSPHORUS OXYCHLORIDE Derivation Summary for Phosphorus Oxychloride AEGL-1 VALUES 10 min 30 min 1h 4h 8h Not Not Not Not Not recommended recommended recommended recommended recommended Reference: Not applicable Test Species/Strain/Number: Not applicable Exposure Route/Concentrations/Durations: Not applicable Toxicity End Point: Not applicable Time Scaling: Not applicable Concentration/Time Selection/Rationale: Not applicable Uncertainty Factors/Rationale: Not applicable Modifying Factor: Not applicable Animal to Human Dosimetric Adjustments: Not applicable Data Adequacy: Neither quantitative exposure-response data nor odor threshold data were available for assessing AEGL-1 type effects for phosphorus oxychloride. Therefore, AEGL-1 values are not recommended.
|
From page 248... ...
248 Acute Exposure Guideline Levels AEGL-2 VALUES Continued 10 min 30 min 1h 4h 8h Not Not Not Not Not recommended recommended recommended recommended recommended Data adequacy: Exposure-response data on nonlethal toxic responses were not available for developing AEGL-2 values for phosphorus oxychloride. The absence of such data precludes estimating AEGL-2 values by reducing AEGL-3 values.
|
From page 249... ...
Phosphorus Oxychloride 249 APPENDIX C FIGURE 5-1 Category plot for phosphorus oxychloride.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.