Skip to main content

Currently Skimming:

Letter Report
Pages 1-12

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 1...
... Haas, Ph.D. Chair, Committee to Review Risk Assessment Approaches for the Medical Countermeasures Test and Evaluation Facility at Fort Detrick, Maryland
From page 2...
... The proposed site of the 492,000-square-foot facility is on the north side of the fort's National Interagency Biodefense Campus.1 The facility will be designed to handle infectious agents that are considered Category A and Category B under the Centers for Disease Control and Prevention schedules and that require safety precautions to the extent of animal biosafety level-3 (ABSL-3) and ABSL-4 and biosafety level-3 (BSL-3)
From page 3...
... Technical input may include, but may not be limited to, a proposed work plan for preparing risk assessments as well as information on the selection of agents, scenarios, and models to be used in the risk assessments. The committee may also be asked to review preliminary model results for the quantitative risk assessments and any qualitative assessments developed where data may be insufficient for quantitative modeling.
From page 4...
... See Communication section below for discussion of the importance of clarifying who will be responsible for conducting and approving risk assessments of other agents when they are added to the research portfolio. Range of Validity Because Facility Has Not Been Designed In the first letter report, this committee stated that "a sufficiently detailed understanding and characterization of the design and engineering controls of the facility are needed to perform the SSRA adequately.
From page 5...
... TABLE 1 Activity Resulting in Potential Release of Select Agents, 2003-2009 Activity No. Potential Release Events Animal bite or scratch 11 Needlestick or sharps injury 46 Equipment mechanical failure 23 Personal protective equipment failure 12 Loss of containment 196 Procedural issue 30 Spill 77 Total release events 395 SOURCE: CDC, unpublished material, Nov.
From page 6...
... . Data Quality Standards for Literature Used A retrospective historical analysis forms the basis of much of the proposed risk assessment approach.
From page 7...
... and as appendixes for the other five organisms or class of organisms. The end point of all risk assessments in this project are human infections, and the utility of these maps is that they provide an overview of all possible routes of infection, from the initial event (accidental exposures in the laboratory and accidental or intentional releases from the laboratory)
From page 8...
... The work plan should include clear statements on the precise format and techniques of a qualitative risk assessment, as well as its goals and outcomes. CONDUCT OF THE QUANTITATIVE RISK ASSESSMENT The goals of a quantitative risk assessment are to determine with specificity the extent and magnitude of adverse consequences associated with a policy option, scenario or decision.
From page 9...
... The use of quantitative risk assessment requires inputs on exposure and dose response. In the context of the MCMT&E facility, because the building is not yet designed, the most appropriate method to estimate exposure extents and likelihoods (which would be needed as inputs to quantitative risk assessment)
From page 10...
... from the research programs at Fort Detrick may lead to disease outbreaks in the surrounding community. Therefore, the committee compliments BSA Environmental Services, Inc., for its plans to devote a large amount of effort to address community concerns through risk communications.
From page 11...
... 2011. Work Plan: Site-Specific Risk Assessment for the Medical Countermeasures Testing and Evaluation Facility at Fort Detrick in Frederick County, Maryland.
From page 12...
... 2007. Technical Input on the National Institutes of Health's Draft Supplementary Risk Assessments and Site Suitability Analyses for the National Emerging Infectious Diseases Laboratory, Boston University: A Letter Report.


This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More information on Chapter Skim is available.