Biosecurity Challenges of the Global Expansion of High-Containment Biological Laboratories Summary of a Workshop (2012) / Chapter Skim
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5 Paths from Assessments to Functional Labs (Breakout Sessions)
5 Paths from Assessments to Functional Labs (Breakout Sessions)
Pages 39-52
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From page 39... ...
BREAKOUT SESSION PRESENTATIONS Meeting International Biosafety and Biocontainment Standards in Low-resource Settings: The Southeast Asian Experience Stuart Blacksell (Mahidol Oxford Tropical Medicine Research Unit [MORU]
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MORU employs a full time Biosafety Administrator, a 50 percent time Registered Biosafety Professional, and seven biosafety site representatives. To help address the severe regional lack of biosafety experience and fill the required positions, MORU formed a regional twinning partnership with the Australian Animal Health Laboratory.
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From page 41... ...
-3 and BSL-3 areas, was funded by the South Korean government and was initiated in 2005 before most of the current Korean regulations were passed. Construction started in 2007, and the facility was certified using international standards in 2008.
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Two are located in North Africa and one Central Africa, a hotbed for emerging infectious diseases. Although all three are in developing countries, all are well funded through a combination of federal sponsorships, international partnerships, and corporate support.
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Biopharma is also trying to become a World Organisation for Animal Health (OIE) Reference Laboratory for bluetongue disease, sheep pox, African horse sickness, and peste des petits ruminants.
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The emerging viral diseases research unit, for example, studies viral biodiversity of the Central African tropical rainforest, the emergence of human viral diseases, and the fundamentals of cross-species transmission. Past work examined the phylogeny and natural history of Ebola, suggesting that fruit bats serve as a reservoir for the virus and then infect both great apes and humans.
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, the session chair, then led a discussion that elaborated on issues introduced during the talks. BREAKOUT SESSION PRESENTATIONS Georgian Central Public Health Reference Laboratory Colonel Arthur Lyons (United States Army Medical Research and Materiel Command, United States)
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Colonel Lyons then shared lessons learned from each stage in the process. He feels that during the planning and coordination stage it is important to: • Obtain political buy-in and involve the appropriate political level, as ultimately, Ministers and politicians will need to budget for the lab and defend it publicly; • Obtain scientific buy-in and have the right partner country scientific personnel begin planning the scientific work and continue planning throughout the construction process to facilitate a quick start-up upon completion; and • Consider starting public awareness outreach.
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From page 47... ...
, a large number of substandard and insecure labs, and numerous poorly documented pathogen collections. Canada and the Kyrgyz Republic ultimately agreed to undertake a comprehensive assistance program including development of national biosafety guidelines, training, a twinning program with Canada's Winnipeg lab, scientific engagement, help establishing the Biosafety Association for Central Asia and the Caucasus, interim security upgrades, and a new biological containment laboratory.
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From page 48... ...
In addition to its research, diagnostics, education, publishing, and project development duties, Pendik Institute also serves as the national reference lab for sheep and goat pox, animal brucellosis, animal mycoplasmosis, anaerobic diseases, Theileria annulata, Marek's diseases, and the detection of drug residues. Pendik Institute also produces 17 vaccines and 22 serums, antigens, and biological materials.
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From page 49... ...
In addition to polio vaccine, Chumakov Institute has also produced vaccines against yellow fever, influenza A, hepatitis A, rabies, tick-born encephalitis, Crimean-Congo hemorrhagic fever (CCHF) , and measles as well as cell culture media and hantavirus testsystems.
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Several people noted that more countries are now producing their own HEPA filters and components and that many donors are training local technicians to service BSCs. One person indicated that it might be useful to have a group that certifies BSL-3 equipment in Africa, and others suggested requiring suppliers and manufacturers to train local maintenance and engineering personnel as part of their contract.
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From page 51... ...
One person suggested that initial training emphasize routine tasks, such as the proper use of personal protective equipment, and another suggested that some entity certify people as being qualified to work in BSL-3 labs. One argued that institutions, in spite of the expense involved, needed to be willing to fail people during internal training; another added that people who don't follow rules should be removed.
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