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International Animal Research Regulations Impact on Neuroscience Research: Workshop Summary (2012) / Chapter Skim
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7 Core Principles for the Care and Use of Animals in Research
Pages 61-70

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From page 61...
... BALANCING SCIENTIFIC PROGRESS AND ANIMAL WELFARE The goal of biomedical research is to understand living systems, with a particular focus on human biology and human disorders, Nakamura said. Scientists can learn much about the principles of human biology and behavior from animal models and use discoveries in human biology to help understand other animals.
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From page 62...
... Core Principles According to MacArthur Clark, three basic core systems are necessary in animal research regulations: a system of authorization of people, places, and projects; ethical, impartial, and independent evaluation of projects based on a cost-benefit balance; and impartial and independent verification of compliance involving some form of inspection. MacArthur Clark referred participants to Chapter 7.8 of the World Organisation for Animal Health (OIE)
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From page 63...
... Another goal would be to identify marginal projects as early as possible and develop a separate process to review them and facilitate faster decisions. Reject the project and provide reasons, or accept the marginal project and build in milestones that are not overly restrictive, MacArthur Clark asserted.
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From page 64...
... There could also be modules of additional training appropriate to the particular needs of the individual and continued training to maintain developing skills. Harmonization and Consistency Harmonization is a key aim of the EU directive, MacArthur Clark noted.
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From page 65...
... Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training.1 U.S. Government Principles for the Utilization and Care of Vertebrate Animals Used in Testing, Research, and Training Brown reviewed the aspects of the three primary entities involved in oversight of animal use in the United States.2 The PHS Policy requires an institutional program of animal care and use, with an IACUC appointed by the chief executive officer.
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From page 66...
... More recently, the International Council for Laboratory Animal Science (ICLAS) and CIOMS convened a working group to revise and update the International Guiding Principles.
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From page 67...
... PHARMACEUTICAL PERSPECTIVE Margaret Landi, vice president of Global Laboratory Animal Science and chief of Animal Welfare and Veterinary Medicine for GlaxoSmithKline (GSK) Pharmaceuticals,5 noted that a challenge for multinational corporations is developing an animal care system that meets the required standards, but that also recognizes the global diversity of rules, regulations, policies, and guidance.
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From page 68...
... DEVELOPING CORE PRINCIPLES Timo Nevalainen, from the National Research Council's Institute of Laboratory Animal Research (ILAR) Council, said there are several potential target populations for core principles of animal research: specific fields of research (e.g., neuroscience)
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From page 69...
... First, should the scientific community be proactive and establish core principles for the regulators? One example of core principles of animal welfare developed by scientists and referred to by government policy makers is the ILAR Guide for the Care and Use of Laboratory Animals (NRC, 2010)
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From page 70...
... 70 INTERNATIONAL ANIMAL RESEARCH REGULATIONS BOX 7-3 Summary of Session Points • arget populations for core principles of animal research may be specific fields T of research, institutions, and regulators. • onsiderations for animals in research could include C o elfare: Minimize pain and distress and improve overall well-being.
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  • human biology

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  • involving animals
  • animal health
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  • developing core

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  • project authorization
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  • minimize pain
  • animal work
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  • animal models


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