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From page 1... ... in 1949, had accumulated the largest collection of human pathology specimens in the world and established itself as a premier consultation, education, and research facility. Perhaps its best known contribution to science was as the source of some of the bio specimens used to sequence the genome of the 1918 influenza virus that killed over 40 million people worldwide and as the home institution of the lead investigator in the research (Morens et al., 2008; Taubenberger et al., 2007) Read the entire page →
From page 2... ... � The tissue repository currently contains paraffin embedded tissue, glass slides, wet (formalin-fixed tissue) and frozen tissue; some of it is not usable for consul tation, education, and research given current technology. Read the entire page →
From page 3... ... Most of the remaining 4.2 million accessions are from military medical facilities closed under BRAC Commission proceedings. They differ from those in the Central Collection in that they include the complete array of data and specimens collected in the course of the provision of routine medical care. Read the entire page →
From page 4... ... . Data related to specimens in the BRAC Collection vary because the submitting military base, rather than the repository, determined which information was collected, but is typically more limited than in the Central Collection. Read the entire page →
From page 5... ... . The assessment concluded that the utility of Central Collection specimens for research purposes depended on the age of the specimen, with the most recently acquired specimens having the fewest aberrations and the largest amount of associated clinical data. Read the entire page →
From page 6... ... The committee recommends that the JPC, as part of its plan for improving the use of repository materials in research, evaluate the strengths and limitations of the collection to the extent permitted by its resources and current science and technology, consider how to enhance the repository's value given the JPC's organizational and budgetary constraints, and formulate its retention policy and dissemination management and marketing strategies accordingly. In this regard, the committee believes that it is crucial for the JPC to find ways to engage the professional community in discussion concerning future use of the repository so that it can understand better the potential demand for collection materials and how to facilitate their use. Read the entire page →
From page 7... ... The committee recommends that the JPC develop protocols for determining when to retain potentially useful materials and when to dispose of specimens that have no special research or educational value and are past the point of required retention for clinical use. The committee recommends that the criteria for determining when specimens should be disposed of include whether the specimens fall into any of these categories: � Wet tissue specimens and slides that have been obviously contami nated, desiccated, or otherwise damaged. Read the entire page →
From page 8... ... The information available to the committee suggests that the BRAC Collection of materials has no greater value for education or research purposes than the collections of pathology materials found in hospitals comparable with the facilities that transferred them. Therefore, the committee recommends that the JPC retain materials in the BRAC Collection for potential clinical consultation only for as long as required by CAP or CLIP�CLIA guidelines4 and requirements, whichever specifies the longer period. Read the entire page →
From page 9... ... Use in research The policy landscape governing research on clinically collected specimens that are assembled by pathologists and then made available for research use is in transition. It is important to consider which approaches for using archived clinical data and specimens in research and which approaches for accessioning new data and specimens accomplish the goals of protecting and respecting source individuals, meeting public expectations, and supporting the efficient functioning of the repository. Read the entire page →
From page 10... ... -- a clear statement that no access will be allowed without the review and approval of an IRB. -- user-friendly means by which people may ask questions or re quest that a good-faith effort be made to determine whether the repository holds specimens from them with the option to request 5The most current repository protocol regarding review of research proposals available at the time of this report was contained in AFIP Regulation 70-1, AFIP Research Program, dated June 7, 2005. Read the entire page →
From page 11... ... Use of Consultation Materials from Federal Facilities and Civilian Providers Access by researchers to human materials that entered the JPC repository from federal facilities and from civilian providers6 is generally governed by the same legal requirements and ethical standards. Additional protections regarding research on human subjects, especially requirements regarding informed consent, do apply to U.S. Read the entire page →
From page 12... ... There may also be merit in digitizing all new cases coming to the repository and the committee suggests that the JPC consider whether it is feasible given economic and logistical circumstances. And, the committee believes that the JPC would derive value from pursuing research partnerships with the Department of Veterans Affairs to examine questions regarding the health consequences of military service and the determinants of disease and wellness. Read the entire page →
From page 13... ... The JPC does not have any specific policy regarding how the depletion of a repository specimen should be factored into decisions regarding access to it, beyond ensuring that all applicable retention requirements are met. That should change to ensure that the repository remains a resource for otherwise unobtainable material. Read the entire page →
From page 14... ... 2011. Responses to questions posed by the Institute of Medicine Committee on the Review of the Appropriate Use of AFIP's Tissue Repository Following Its Transfer to the Joint Pathology Center by COL Thomas P Read the entire page →
From page 15... ... :79-161. JPC (Joint Pathology Center) Read the entire page →

From page 1...

... in 1949, had accumulated the largest collection of human pathology specimens in the world and established itself as a premier consultation, education, and research facility. Perhaps its best known contribution to science was as the source of some of the bio specimens used to sequence the genome of the 1918 influenza virus that killed over 40 million people worldwide and as the home institution of the lead investigator in the research (Morens et al., 2008; Taubenberger et al., 2007)

Summary Pages 1-16

Summary
Pages 1-16