Transforming Glycoscience A Roadmap for the Future (2012) / Chapter Skim
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6 Deciphering the Glycome for Human Health and Sustainability: Findings, Recommendations, and Roadmap
6 Deciphering the Glycome for Human Health and Sustainability: Findings, Recommendations, and Roadmap
Pages 135-142
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From page 135... ...
Over the course of its data-gathering efforts and deliberations, the committee concluded there is good reason that our understanding of glycans pales in comparison to what is known about nucleic acids, proteins, and lipids: Glycoscience lacks the necessary technologies needed to fully decipher the glycome and make sense of the last step of information flow that transforms genetic information into phenotype. However, the committee also determined that enormous advances in technologies, spurred by the Human Genome Project, the modern molecular biology revolution, nanotechnology, microfluidics, information technologies, and other fields, have created a new opportunity to create the tools and methods needed to bring glycoscience up to par with genomics and proteomics.
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From page 136... ...
How to most effectively deploy resources to achieve these priorities and to enable glycoscience to contribute to advances in health, energy, and materials science will require additional discussion among multiple federal agencies as well as members of the broader scientific community, a discussion that extends beyond the committee's mandate in this report. The committee's findings are detailed in preceding chapters; the findings fall into four general categories that can be summarized here.
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From page 137... ...
· Continued advances in molecular modeling, verified by advanced chemical analysis and solution characterization tools, can gener ate insights for understanding glycan structures and properties.
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From page 138... ...
Within 10 years, have synthetic tools to be able to synthesize uniform batches, in milligram quantities, of all linear and branched glycans that will enable glycan arrays for identifying protein binding epitopes, provide standards for analytical methods development, and enable improved polysaccharide materials engineering and systematic studies for all fields to be conducted. This includes methods for synthesis of structures with isotopic enrichment of specific desired atoms that may be needed for a wide variety of studies.
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From page 139... ...
Within 10 years, have the ability to routinely determine the complete carbohydrate structure of any glycan or polymer repeat sequence including branching, anomeric linkages between glycans, and substituents. Within 15 years, have the ability to determine glycoforms (a complete description of molecular species within a population that have the same polypeptide sequence)
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From page 140... ...
Roadmap Goals Within 5 years, develop a long-term-funded, centralized glycan structure database with each entry highly annotated using standards adopted by the community and all the world's repositories of glycan structures. The database should be cross-referenced and open source to allow the community to develop database resources that draw on this resource and
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From page 141... ...
. To achieve these goals, the committee notes that mechanisms would need to be implemented to define appropriate glycoscience competency and to incorporate glycoscience topics into educational frameworks at multiple levels.
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From page 142... ...
Research can make significant contributions toward understanding and improving human health, creating next-generation fuels and materials, and contributing to economic innovation and development. Now is the time for glycoscience to be embraced broadly by the research community.
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