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Transforming Glycoscience A Roadmap for the Future (2012) / Chapter Skim
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Appendix B: The Landscape of Current Research in Glycoscience: Additional Information
Pages 167-176

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From page 167...
... The examples provided are not meant to imply endorsement by the committee or the National Research Council (NRC)
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From page 168...
... , with total funding of approximately $59 million.1 The National Institute of General Medical Sciences (NIGMS) is a central contributor to many NIH glycoscience efforts, although investments exist for other institutes, such as the National Cancer Institute (NCI)
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From page 169...
... Although NSF has not developed funding solicitations specifically dedicated to glycoscience, it receives relevant proposals under a range of programs. An approximate and unofficial portfolio estimate indicates that approximately 5 percent of chemical synthesis submissions address carbohydrate synthesis strategies, whereas approximately 5 to 10 percent of biomaterials submissions involve polysaccharides or sugars in some fashion (personal communication from Kelsey Cook, Tingyu Li, and David Berkowitz, NSF Division of Chemistry, and David Brant, NSF Division of Materials Research, phone conversation, 11/18/2010)
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From page 170...
... ; Research Resource for Integrated Glycotechnology (funded by NIH) ; Southeast Collaboratory for Biomolecular NMR (funded by NIGMS and the Georgia Research Alliance; research initiatives on GLYCAM/AMBER Modeling Tools for Glycoscience; Monoclonal Antibodies for Plant Cell Walls (funded by NSF)
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From page 171...
... The data gathering conducted by the committee was intended to be fairly broad in scope in order to identify centers of expertise beyond the intersection of glycoscience with human health. Again, the list below should not be considered comprehensive; it is meant to provide a sense of major ongoing efforts.
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From page 172...
... Other ongoing efforts in Canada include those at the University of Toronto and the National Research Council Canada Institute for Biological Sciences in Ottawa. B.2.2 United Kingdom and Europe Within the United Kingdom, glycoscience research is supported by such organizations as the Wellcome Trust, the Engineering and Physical Sciences Research Council, the Biotechnology and Biological Sciences Research Council, and the Medical Research Council; centers of activity include Imperial College London and the University of Oxford and University of Dundee.
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From page 173...
... with the goal of deciphering sugar chain­based signals that regulate integrative neuronal functions. Glycoscience research centers in Japan include the National Institute of Advanced Industrial Science and Technology, Kyoto University, University of Tokyo, and RIKEN, which includes the RIKEN Omics Science Center, the RIKEN Bioinformatics and Systems Engineering Division, and the System Glycobiology Research Group.
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From page 174...
... , which focuses on understanding the roles of glycans in disease through investigations of both mammalian and microbial glycomics and on development of enabling technologies such as new synthesis and analytical tools. Glycomics research is also conducted at Macquarie University in Sydney, and established programs that analyze plant cell walls include those at the University of Melbourne and the ARC Centre of Excellence in Plant Cell Walls at the University of Adelaide (http://www.adelaide.
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From page 175...
... GlycoFi, established in 2000 to develop yeast-based production systems for protein-based drugs, was acquired by Merck in 2006. Novo Nordisk conducts clinical trials for the hemophilia treatment GlycoPEGylated factor IX, which contains polyethylene glycol groups linked to glycan chains through carbohydrate engineering to prolong the pharmacokinetics.
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Key Terms

  • glycoscience efforts
  • plant cell
  • cell walls
  • science center
  • functional glycomics

  • bioenergy science
  • college london
  • grant mechanism
  • nsf division
  • ongoing efforts

  • glycan mass
  • doe office
  • microbial complex
  • enzyme replacement
  • list below

  • macquarie university
  • total funding
  • analytical chemistry
  • data gathering
  • imperial college

  • glue grant
  • canada include
  • mass spectral
  • glycoscience tools
  • glycoscience outside

  • frontier research
  • bioprocessing research
  • foundation research
  • bioenergy research
  • rials research


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