Returning Home from Iraq and Afghanistan Assessment of Readjustment Needs of Veterans, Service Members, and Their Families (2013) / Chapter Skim
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Appendix D: Summary of Federally Funded Research Related to OEF and OIF Populations
Appendix D: Summary of Federally Funded Research Related to OEF and OIF Populations
Pages 579-642
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D SUMMARY OF FEDERALLY FUNDED RESEARCH RELATED TO OEF AND OIF POPULATIONS Table D.1 lists federally funded research related to Operation Enduring Freedom (OEF) and Operation Iraqi Freedom (OIF)
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Specifically, researchers compared the relative efficacy of an alternative (principal Trauma Stress in Combat therapeutic approach, a mindfulness-based treatment, with a psychoeducation investigator) /VA Veterans: Comparing treatment in reducing symptoms of posttraumatic stress disorder (PTSD)
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Army Medical Center 2009-09 Motivational Interviewing to In this study, a randomized controlled trial of 1,000 OEF/OIF veterans was used to Karen H Seal/San Engage OEF/OIF Veterans in evaluate the efficacy of telephone-administered motivational interviewing Francisco VA Mental Health Treatment compared to informational support sessions.
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of Naval Research, Traumatic Stress Disorder Virtual Reality (PTSD) in Non-Combatants Medical Center 2009-10 Dissemination Evaluation of A postdeployment education materials booklet was disseminated to 3,400 veterans Constance R
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Assessments were made after 6 Randomized Controlled Trial completed sessions and after 3 and 6 months (N = ?
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identify specific targets in the PTSD treatment pathway amenable to intervention. 2010-07 Exposure Therapy for Chronic In this study, 36 OEF/OIF veterans with chronic PTSD of at least 3 months Sheila Rauch, Ann PTSD: Efficacy and Mechanisms duration were randomly assigned to 15 sessions of either prolonged exposure (PE)
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2010-09 Efficacy of Mantram Repetition This study was a randomized, controlled clinical trial to compare a mantram group Jill E Bormann, VA on PTSD Symptoms in Veterans intervention (6 weeks, 90 minutes per week in small groups)
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Eisen, Mental Health Substance Abuse development of a psychiatric or substance-abuse disorder and associated mental Edith Nourse and Services Needs health and/or substance-abuse service use. A national, stratified random sample of Rogers Memorial 1,300 veterans enrolled for VA care served as the study sample.
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exposure, after 15 HBOT, and 6 weeks post-HBOT. 2010-12 Combined Exposure Therapy and In this study, 40 participants with 9/11-related or Iraq War–related PTSD were JoAnn Difede/Weill D-Cycloserine vs Placebo for assigned to one of two programs -- both included Virtual Reality Exposure Therapy Medical College of Posttraumatic Stress Disorder and standard cognitive-behavioral therapy techniques.
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Krystal, VA Military Service Related Chronic enrolled at 20 VAMC hospitals over a 2-year period. Patients were randomized in a Connecticut Health Post-Traumatic Stress Disorder double-blind manner to risperidone or placebo.
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PTSD symptoms, brain markers, neuropsychological testing of memory, and Rehab Center, and cortisol response to an Iraq-related traumatic script before and after the Decatur/VA intervention were assessed. 2011-03 Evaluation of TBI Screening The aims of this study were to examine factors associated with receipt of the TBI Bridget Smith, Processes and Healthcare clinical reminder (CR)
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Next of kin for Joan M Griffin, Needs of Informal Caregivers to veterans discharged from four VA Polytrauma Rehabilitation Centers were mailed VAMC Improve Outcomes for Traumatic a questionnaire that included demographic information; objective burden; Minneapolis/VA Brain Injury Patients with instrumental, social, cognitive resources, and resiliency factors available; caregiver; Polytrauma caregiver and family outcomes; and patient health and functioning outcomes.
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(with- Virtual Reality Exposure Therapy management of PTSD symptoms in four burned OIF/OEF service members was Gaylord/U.S. Army drawn, did and D-Cycloserine (DCS)
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200 OIF/OEF veterans. Providence/VA 2011-05 Gender Differences in Mental Researchers conducted telephone interviews and medical records reviews on 100 Anna Kline, VA Health Treatment Needs and VA New Jersey patients (50 men and 50 women)
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documentation practices, Phase 1 of April A Gerlock, Detection of Intimate Partner this study reviewed every note in the medical record over 5 years for a random VA Puget Sound Violence sample of 507 veterans enrolled into PTSD treatment.
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2011-07 Randomized Trial of an Online A randomized, controlled trial of 160 service members with PTSD compared an Charles Early Intervention for Combat Internet-based, nurse-assisted, cognitive behavioral self-management program to Engel/NIMH PTSD in Primary Care usual care alone with follow-up at 6 and 12 weeks. 2011-07 Barriers to Mental Health Care Objectives of this study were to (1)
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. 2011-09 Cerebrospinal Fluid Neuropeptide No additional information found.
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Linkage to Treatment soldiers, buddies, and National Guard leadership to develop and pilot test survey Valenstein, Ann items relevant to implementation; develop and pretest survey items relevant to Arbor VA HCS/VA soldier symptomatic and functional status; conduct a small feasibility study to determine response rates and veteran willingness to allow access to linkable Post Deployment Health Assessment/Post-Deployment Health Reassessment data and health services data; and construct a merged, de-identified longitudinal dataset comprised of postdeployment health assessment and reassessment data, MHS/TRICARE, and VA services data from National Guard soldiers in Michigan and comparison states of Indiana and Ohio.
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. 2011-12 Sleep Disturbance in OEF/OIF No additional information found.
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VA Functional Impairment in Veterans 2012-03 The Effects of Explosive Blast as This study examined the neural consequences of blast exposure by comparing the Scott R Compared to Post-Traumatic functional and structural brain characteristics of 180 OIF National Guard soldiers Sponheim/Minnesot Stress Disorder on Brain Function who returned from deployment who have blast injury, blast injury and PTSD, a Veterans Research and Structure PTSD, and no blast injury or PTSD (45 demographically similar subjects in each Institute group)
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2012-04 Rehabilitation Strategies to No additional information found.
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Buffalo/VA 2012-04 Access to Treatment and This study was a retrospective observational cohort study of patient-level Steven Daniel Pizer, Outcomes for Veterans with administrative data extracted from VA, Medicare, and Medicaid records over the VA Medical Center, Substance Use Disorders period from January 1, 2001, to December 31, 2005. These data were augmented Jamaica Plain by program-level survey data from the VA Drug Abuse Program Survey and the Campus/VA National Survey of Substance Abuse Treatment Services.
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68 OEF/OIF veterans with PTSD were randomly assigned to CBT plus DCS or CBT plus placebo. Assessment interviews were conducted by independent evaluators and self-report occurred at pretreatment, posttreatment, and at the 3- and D-23 6-month follow-ups.
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2012-08 Supporting Education Goals of In this study, 40 OEF/OIF veterans with PTSD were randomly assigned to either a Marsha Langer OIF/OEF Veterans with PTSD: group that received weekly supported education intervention or a group that Ellison, Edith Pilot Process and Outcome received services as usual plus an hour of attentive intervention not focused on Nourse Rogers education. Memorial Veterans Hospital, Bedford/VA 2012-08 PROJECT VALOR: A longitudinal registry of 1,600 male and female service members was created to Terence M
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Researchers Richard Rodebush Veterans compared the stepped-case intervention to usual care in 300 OEF/OIF veterans VAMC/VA with chronic and disabling musculoskeletal pain to evaluate the impact of the intervention on pain-related disability, work function, psychological distress, and other outcomes. 2012-09 Adjunctive Biofeedback In this study, 30 OIF/OEF veterans receiving care for PTSD at CBOCs were Timothy Kimbrell, Intervention for OIF/OEF PTSD randomized to a 24-week course of StressEraser or usual care.
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VA Induced Traumatic Brain Injury 2012-09 Long-Term Outcomes in Burned This study used data from U.S. Army Institute of Surgical Research Valerie Ann OEF/OIF Veterans (LOBO)
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(The study Trial and Mechanistic Study was also approved by the Institutional Review Board of the VA Ann Arbor.) Combat veterans were randomly assigned to either the meditation or the standard group psychotherapy.
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develop and Healthcare, and standardize Strength at Home Couples Group for male combat veterans, including Tracie Shea, the development of a clinician-friendly intervention manual detailing Strength at Providence Home Couples Group, along with intervention adherence measures and therapist VAMC/VA training and certification procedures; (2) test the efficacy of Strength at Home Couples Group for OEF/OIF/OND veterans by conducting a multiple-site randomized trial comparing 10 sessions of Strength at Home Couples Group to 10 sessions of a supportive group therapy condition; and (3)
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2012-10 A Head-to-Head Comparison of This randomized, head-to-head study compared 40 PTSD patients treated with Robert N Virtual Reality Treatment for Post Virtual Reality Exposure Therapy to 40 PTSD patients treated with Augmented McLay/U.S.
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Rajeev Ramchand Phase 1 and Terri Tanielian, RAND Corporation/ Elizabeth Dole Foundation 2012-12 Cognitive Behavioral Treatment In this study, 11 individuals with comorbid PTSD and substance abuse resulting JoAnn Difede/Weill of Posttraumatic Stress Disorder from the attacks of September 11, 2001, or from military service in Iraq were Medical College of Enhanced by Virtual Reality for treated with cognitive behavioral therapy enhanced with the use of a virtual Cornell Individuals with PTSD and environment. Substance Abuse 2012-12 Strength, Pain, and Function in In this study, 60 OEF/OIF amputees were randomly assigned to either the nurse- Laura A
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Hospital/VA, University of South Carolina 2012-12 Evaluation of Approaches to In this study, effectiveness of FM use and/or auditory training for OEF/OIF Gabrielle Saunders, Auditory Rehabilitation for Mild veterans with mTBI was examined in a randomized clinical trial of 132 veterans. Portland VAMC/VA TBI 2012-12 Breaking the Cycle IV: Military The study compared the efficacy of Trauma Affect Regulation: Guide for Julian Ford/ PTSD (MPTSD)
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Hunt, Seeking of Returning Veterans in including 500 veterans) , researchers fielded a Web-based survey to collect and University of Rural Community Colleges analyze data to address the following specific aims: (1)
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Anita Chandra, Children of Deployed Military RAND Corporation/ Personnel National Military Family Association Complete Needs of Servicemembers and No additional information found. Andrew Parker, Lisa (awaiting Their Families for Information on Meredith, RAND DOD Traumatic Brain Injury (TBI)
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Because the random effects modeling uses open-ended, qualitative data this statistical analysis allows this study to go beyond reliance on preestablished satisfaction items and instead capture very specific reasons for satisfaction and dissatisfaction with VA health care as described by the veterans themselves. 2013-03 Mental Health and Service The study will document psychopathology, health risk behavior, and mental health Sandro Galea, Utilization Among Reserve and service utilization among National Guard and to identify personal factors (e.g., Columbia National Guard Forces sociodemographic factors, social supports)
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Simmons, Veterans with Blast-Related mTBI, and mTBI with PTSD. In the short run, researchers may be able to develop a VA San Diego Traumatic Brain Injury more exact model for the neural effects of these disorders in the veteran population Healthcare System/ (N = ?
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OIF/OEF Veterans with will be randomly assigned to either the cognitive strategy training group or the Storzbach, (Portland Cognitive Disorder usual care group to evaluate its efficacy.
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HSR&D/RR&D Traumatic Brain Injury Center of Excellence/VA 2013-06 PTSD Hyperarousal Symptoms In this study, 50 volunteers with at least moderate hyperarousal will be randomized Walton Roth, VA Treated with Physiological Stress to treatment consisting of five sessions of individual physiological relaxation Palo Alto Health Management training with electromyographic feedback and with capnographic feedback over a Care System/VA 4-week period or to a 2-month waiting period after which they also may receive this therapy. The waiting-list group and a nonanxious control group will be tested psychophysiologically twice at the same interval as the patients before and immediately after treatment.
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Depression and PTSD in remission rates of urogenital symptoms, especially urge urinary incontinence and Bradley, MD, OEF/OIF Women Veterans urinary frequency, in a representative population of OEF/OIF women veterans; and MSCE, VA Medical (2) identify the impact of depression and PTSD symptoms, a history of sexual Center, Iowa City assault, and deployment-related factors on the prevalence and 1-year incidence of urogenital symptoms, especially urge urinary incontinence and urinary frequency (N = 2,127)
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assess its acceptability to family members using project evaluations and focus groups discussions. 2013-08 Initial Randomized Controlled The study is a randomized, controlled trial of Acceptance and Commitment Ariel J
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, an evidence-based treatment National Center for for PTSD, to Present Centered Therapy in order to determine whether the results of PTSD/VA Boston CPT exceed those of receiving a therapy that focuses on current problems rather Healthcare System than past trauma in a group format. A second purpose is to conduct a randomized controlled trial to compare group and individual CPT-C for the treatment of PTSD in OIF/OEF military personnel (N = 400)
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VA Control in Traumatic Brain Injury 2013-09 Prazosin and Combat Trauma This 26-week randomized double-blind placebo-controlled study is designed to Murray Raskind, PTSD (PACT) demonstrate both short-term efficacy and long-term effectiveness of prazosin for Elaine Peskind, VA PTSD (N = ~326)
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Texas Health Many service members prefer to see behavioral health providers in primary care Science Center at rather than the mental health clinic. The researchers hope to learn if a brief San Antonio, treatment for PTSD in primary care can be just as useful as more traditional Brooke Army treatment given in the mental health clinic.
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for Ralph H Johnson At-Risk OIF-OEF Service Men OIF and OEF veterans with PTSD symptoms and (2)
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The study's primary outcome variable will be time to relapse to heavy drinking. Secondary outcome measures will include proportion of heavy drinking days, severity of PTSD symptoms measured by the Clinician-Administered PTSD Scale, severity of depressive symptoms measured by the Hamilton Depression Rating Scale, and psychosocial outcome measured by the Community Integration Questionnaire (N = ?
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An expert panel will be used to prioritize adaptations based on pilot study findings, as well as identify specific aims for tool production. Local stakeholders will participate in a tailoring process specific to each clinic.
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The primary aim of the proposed investigation is to evaluate the differential physiological impact of negative marital interactions on OEF and OIF veterans, with and without PTSD, and their spouses. 2014-05 A Brief Intervention to Reduce The goal of this study is to evaluate the efficacy of the safety planning intervention Marjan Holloway, Suicide Risk in Military Service on suicide ideation, suicide-related coping, and attitudes toward help seeking for Henry M
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on Post- veterans diagnosed with PTSD and their partners. This study will examine the Roudebush VAMC, Traumatic Stress Disorder effects of this integrated intervention on PTSD symptoms and intimate relationship Indianapolis VA/VA (PTSD)
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The efficacy of ICBT will be tested among 64 veterans who screen positive for both disorders and are randomly assigned to either ICBT or standard treatment. 2014-06 Psychological Stress and Risk of In this study, a database of more than 200,000 veterans returning from Iraq and Beth Cohen, Cardiovascular Disease (CVD)
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, with separate analyses for OEF/OIF veterans and all veterans. 2014-07 Novel Treatment of Emotional The objective of this study is to determine if adding repetitive transcranial magnetic John Hart, Jr., Dysfunction in PTSD stimulation prior to Cognitive Processing Therapy significantly alters measures of University of Texas, arousal in individuals with combat related PTSD and improves clinical outcome.
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2014-08 Phase IV Study of Cognitive This is a prospective, randomized, control treatment trial of cognitive rehabilitation Douglas B Rehabilitation Effectiveness for for OEF/OIF service members with a history of mTBI and persistent (3–24 months Cooper/Brooke Mild Traumatic Brain Injury post-injury)
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Approximately 200 will randomly selected from the Vasterling, VAMC, Cohort Study larger group to take part in an in-person assessment which involved taking a small Jamaica Plains/VA subset of neuropsychological tasks. 2014-09 Identifying and Validating This project establishes a line of inquiry examining patterns and trajectories of Mary Jo Pugh, Complex Comorbidity Clusters in comorbidity, risk factors, and patient outcomes in OEF/OIF VA patients using a South Texas Health OEF-OIF Veterans team comprised of VA, Army, Air Force, and Navy investigators.
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. 2014-11 Comparing Virtual Reality This study is evaluating the efficacy of virtual reality exposure therapy (VRET)
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, represents a novel treatment that integrates cognitive-behavioral therapy Medical University Iraqi Freedom Veterans with for SUDs with prolonged exposure therapy for PTSD. In earlier studies with of South Post-Traumatic Stress Disorder civilians, COPE has demonstrated efficacy in reducing alcohol and drug use Carolina/Medical and Substance Use Disorders severity, PTSD symptoms, and associated mental health problems (e.g., depression, University of South anxiety)
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, represents a novel treatment that integrates cognitive-behavioral therapy for SUDs with prolonged exposure therapy for PTSD. In this hybrid Stage Ib/Stage II study, researchers will (1)
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The purpose of the second phase of the study is to evaluate the effectiveness of the multicomponent cognitive-behavioral treatment in comparison to standard PTSD treatment in military personnel returning from active duty (N = ?
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identify the functional outcomes associated with abnormal performance on tests of central processing, and (3) improve understanding of the ways in which blast-exposure resembles and differs from both the normal aging process and non-blast-related TBI in terms of performance on tests of central auditory processing (N = 200)
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Peters Randomized Clinical Trial of treatment shown to be effective in the treatment of PTSD. The augmentation builds VAMC/Mount Sinai Hydrocortisone Augmentation of on both the translation of neuroscience findings demonstrating the effects of School of Medicine Prolonged Exposure Therapy glucocorticoids on learning and on empirical clinical findings from other investigators demonstrating beneficial effects of glucocorticoids in reducing traumatic memories in trauma-exposed persons (N = 60)
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In addition, the investigators are examining Ann Arbor Combination for Post-Traumatic predictors of response to these two treatments and how PTSD symptoms, thoughts, Healthcare System/ Stress Disorder (PTSD) in and biological factors may be changed by such treatments.
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2017-04 Neuroimaging and Cognitive This study will address some of these gaps in the literature by evaluating the neural Kathleen Pagulayan, Correlates of Repetitive Blast- underpinnings of persisting cognitive difficulties in veterans with a history of VA Puget Sound Related mTBI repeated blast-related mTBI. Specifically, preliminary research involving OEF/OIF Healthcare System veterans with a history of blast-related mTBI has found evidence of both reduced working memory on neuropsychological measures and cerebellar abnormalities that are visible on neuroimaging.
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Awaiting Preventing and Managing No additional information found. Rosalie Pacula, IRB Prescription Drug Misuse Among RAND Corporation/ approval Military Personnel DOD (as of 09/2012)
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Preparing Availability and Efficacy of No additional information found. Ryan Brown and IRB Military-Culture Appropriate Grant Marshall, application Psychological Health Treatment RAND Corporation/ (as of for Geographically Distant DOD 09/2012)
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Several Innovative Practices to Support No additional information found. Carrie Farmer, reports Psychological Health and Well- RAND Corporation/ available Being DOD on RAND website, several others forthcoming Studies with Missing or Incomplete Information*
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The study will also survey 200 military families from deployed support brigades of Fort Drum, New York. Unknown Post-Traumatic Stress Disorder This study will evaluate the feasibility and efficacy of a treatment delivery method Alan Peterson, In-Home Therapy Clinical Trial that could help overcome these barriers to care and make effective PTSD treatment University of Texas, Award more accessible to underserved military personnel and veterans.
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The PreSTINT program includes an educational component in which two arousal reduction techniques are presented. During a virtual reality simulated mission, soldiers are trained to control excessive arousal levels while focusing on the mission at hand.
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