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Behavioral Measures of Neurotoxicity (1990) / Chapter Skim
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Animal Models: What Has Worked and What Is Needed
Pages 184-188

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
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From page 184...
... Rats appear to be very useful in understanding many of the actions of OPs, and also in developing therapeutic approaches to OP intoxication. More specifically her work focuses on the receptor changes accompanying acute and subchronic exposures, and the importance of age and genetic variables.
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From page 185...
... What is needed is a broad-based program of research to determine directly the extent of differences between strains of stocks of commonly used laboratory species, in terms of both the basic neurobehavioral processes and the effects of chemicals. The evidence suggests that the mechanisms underlying acute OP intoxication, and the development of tolerance, may be very general across species.
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From page 186...
... Caution must be exercised, however, in evaluating pharmacological challenge data to ensure that an altered drug effect following toxicant exposure is not due to dispositional, rather than functional, variables. Deborah Cory-Slechta has indicated two major emphases in behavioral toxicology.
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From page 187...
... . have received little help from their counterparts at the animal level in addressing the issues surrounding the possible adverse effects of long-term solvent exposures on cognitive functioning." Although I wholeheartedly endorse this position, I do not believe it is due to a lack of test methods that can be applied to the problem.
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From page 188...
... 1988. Spatial memory impairment and central muscarinic receptor loss following prolonged treatment with organophosphates.
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Key Terms

  • repeated exposures
  • finding effects
  • neurobehavioral toxicology
  • solvent exposures
  • delayed neurotoxicity

  • reinforcing properties
  • changes accompanying
  • spinal cord
  • evaluate learning
  • genetic considerations

  • rats appear
  • neuropathological studies
  • issues surrounding
  • prolonged treatment
  • notable effect

  • dire health
  • disorder involving
  • developing fundamental
  • interpreting test
  • prominent behavioral

  • functions throughout
  • diisopropyl fluorophosphate
  • psychopharmacology literature
  • challenge data
  • considered refractory

  • david overstreet
  • cognitive function
  • performance depend
  • lead effects
  • evaluating prophylactic


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