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4 Observations and Looking Forward
Pages 61-70

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From page 61...
... It can also be used to select among existing vaccines for investment in a public health setting or to support other vaccine-related investment and implementation decisions. SMART Vaccines should always be used as a tool to discuss values and preferences across various user groups and not as the ultimate determinant of a decision that needs to be made.
From page 62...
... A Vision for the Future Consistent with this guiding principle and strategy, the committee believes that SMART Vaccines will achieve optimal value if the following events occur: 1.  MART Vaccines and its future versions are hosted in an open S source setting on a widely trusted website with a distinct identity and appropriately protected from unwarranted modifications or intrusions.
From page 63...
... This remains true even when a single software system dominates a market, as in word processing, spreadsheet, graphical presentation, relational database management, or statistical analysis. In light of the continuous cycles of improvement required for SMART Vaccines, the committee developed a set of steps to guide future development, which are listed in priority order here: Establishing a Data Architecture If SMART Vaccines is to become a valuable component of decision making in the vaccine enterprise, concerted data collection efforts will need to be initiated and sustained.
From page 64...
... The usability testing may also shed light on the value of developing versions of SMART Vaccines in alternate software and visual design platforms and also in various of the official languages of the United Nations besides English -- for example, Arabic, Chinese, French, Russian, or Spanish. An artist's rendering of SMART Vaccines in the form of a potential tablet application is shown in Figure 4-1.
From page 65...
... As decision sciences and modeling techniques continue to improve, future versions of the software may incorporate improvements in the multiattribute utility theory modeling or the ranking approach used by SMART Vaccines 1.0, and they could offer options for alternative value modeling, such as mathematical programming or analytic hierarchy process.
From page 66...
... Enhanced Applications of SMART Vaccines Comparisons of New and Existing Vaccines, Public Health Prevention, and Treatment This committee was charged with creating a modeling framework that, when fully instantiated, would allow users with different perspectives to create their own rankings of the potential value of new preventive vaccines. While SMART Vaccines was designed to accomplish this specific goal, the committee believes that it can be applied to a broader array of related applications with little or no change in the software structure by assembling the data necessary to describe the particular options being evaluated.
From page 67...
... And improving vaccines for food animals has the additional advantage that it could help reduce the use of antibiotics, thereby reducing the risk of developing highly resistant organisms in both animal and human populations. Disease-Resistant Plants The hybridization and genetic modification of plants to enhance disease resistance is conceptually similar to vaccinating humans or animals against
From page 68...
... Intellectual property laws provide temporary market protection for recouping research and development costs, but ultimately the risks surrounding scientific research and eventual commercial products drive many corporate decisions about new product development. Knowing which attributes are more or less valuable to potential user communities could enhance vaccine developers' decision-making process and ensure that they better understand the values that users place on various potential vaccines as a way of improving their decision making.
From page 69...
... In doing so, it will also attempt to develop a framework for a data warehouse including estimation strategies to create future datasets for the software.


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