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Infectious Diseases of Mice and Rats (1991) / Chapter Skim
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10. Central Nervous System
Pages 222-230

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From page 222...
... Perspective Theiler's murine encephalomyelitis virus (TMEV) infection in mice resembles poliomyelitis virus infection in humans.
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From page 223...
... These produce small plaques in L929 cells, are relatively avirulent, cause chronic demyelinating disease in mice, do not hema~glutinate human erythrocytes, and are not readily cultivated in embryonating eggs. The large-plaque strains are PA, GDVII~ and others that produce large plaques in L929 cells, are highly virulent for mice, may or may not hemagglutinate human erythrocytes, and grow readily in eggs (Lipton, 19801.
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From page 224...
... test, known to give false positive results for TMEV (Kraft and Meyer, 1986; Van Der Lo at, 19863. In naturally infected mice the virus occurs at a low titer in the intestinal mucosa, intestinal contents, feces, and less frequently, in the mesenteric lymph nodes.
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From page 225...
... Even so, the HAI probably still gives a significant proportion of false positives, and the enzyme-linked immunosorbent assay is now considered the test of choice (Kraft and Meyer, 1986; Van Der Loft, 1986~. The complement fixation and serum neutralization tests may also be useful for some purposes, such as comparisons of the antigenic relatedness of TMEV strains (Downs, 19821.
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From page 226...
... 19511. Also, the isolation and quarantine of individual breeding pairs with subsequent selection of TMEV negative progeny have been successful eliminating the infection (Lipman et al., 19871.
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From page 227...
... Spores stain dark magenta or purple with Goodpasture's carbol fuchsin and stain poorly with hematoxylin and eosin (Perrin, 1943b; Weiser, 1965; Shadduck and Pakes, 1 97 1; Wilson, 1 9791. It has been grown successfully in tissue cultures of several cell lines (Shadduck, 1969; Bismanis, 1970; Cox and Pye, 1975; Wailer, 1975; Shadduck and Geroulo, 1979~.
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From page 228...
... The organism also occurs intracellularly in the renal tubular epithelium with or without the presence of an inflammatory response, and in the renal tubular lumens. In chronic infections focal destruction of tubules and replacement by fibrous connective tissue results in small pits on the cortical surface (Yost, 1958, Flatt and Jackson, 19701.
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From page 229...
... Cesarean derivation, barrier maintenance, and improved sanitation of mouse and rat stocks appear to have been effective in reducing the prevalence of E cuniculi in these species in recent decades.
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From page 230...
... Mice experimentally infected with E cuniculi have reduced humoral antibody titers to sheep erythrocytes and reduced proliferative spleen cell responses to mitogens (Niederkorn et al., 1981; Didier and ShadJuck, 1988)
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Key Terms

  • natural disease
  • clinical disease
  • transplantable tumors
  • complement fixation
  • mice results

  • cell lines
  • tmev infection
  • laboratory rats
  • mouse stocks
  • contaminate transplantable

  • van der
  • natural infections
  • tmev resembling
  • human erythrocytes
  • flaccid paralysis

  • encephalomyelitis virus
  • murine encephalomyelitis
  • natural killer
  • transplacental transmission
  • hemagglutinate human

  • intestinal contents
  • killer cell
  • cell activity
  • highly virulent
  • continuous cell

  • chronic demyelination
  • rare occurrence
  • renal tubular
  • demyelinating disease
  • cuniculi infection


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