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Biologic Markers in Immunotoxicology (1992) / Chapter Skim
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Summary
Pages 1-8

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From page 1...
... The Subcommittee on ~mmunoto~cology, compns~ scientists with diverse backgrounds in and knowledge of immunology, toxicology, ~nunotoxicology, risk analysis, and other disciplines, prepared this document. As two previous sum committees on reproductive and developmental touchy and pulmonary toxicity had done, the Subcommittee on fmmUnoto~n cology reviewed research on currently known markers, and it identified and evaluated promising new technologies to find new markers, important research opportunities in the field, and areas where mterdisciplinaly research in environmental health is needed.
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From page 2...
... The committee recommends that research be devoted to testing the analytic accuracy of biologic markers discussed iD this report to facilitate their use in predicting adverse health effects and in identibing causative agents. Markers of in~nunoto~ncity could be useful in epidemiology to confirm causal relationships between environmental e~posures and prevalence of hypersensidnty.
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From page 3...
... The committee recommends the estate lishment of a national registry for autoim" mune diseases to determine the prevalence of these diseases. The use of genetic "a immune~system markers to identify persons who are susceptible to autoimmune diseases should be explored.
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From page 4...
... can involve experimental studies in which conditions are controlled and ejects are subsequently observed ~ a test population, or it can use cohorts or cases in which the test population is observed without the arc~stances bed altered Epidemiologic procedures frequently permit long-term monitor~ of health eliects in large numbers of persons exposed to undefined quantities of a given environmental xenobiotic. Data obtied in such investigations, which cannot be obtained otherwise for normal human populations, can provide information about immunotomc effects.
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From page 5...
... The resulting symptoms could be associated with exposure to ~rntants, chemical or biologic allergens, or mixfores of chemical pollutants, including volatile organic compounds. The committee recommends that studies be conducted on potential methods and guidelines for reducing harmful exposures and adverse consequences of indoor pollution in homes' schools, and the work place.
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From page 7...
... ~ - ~ ~ ~ ~ ~ ~ ~ ~ ologlc Cagers In Im~noto~co~
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Key Terms

  • autoimmune diseases
  • animal studies
  • multiple chemical
  • epidemiologic studies
  • animal models

  • chemical pollutants
  • toxic substances
  • test population
  • epidemiologic research
  • infectious disease

  • environmental xenobiotic
  • confirm causal
  • people living
  • including volatile
  • procedures parallel

  • analytic accuracy
  • human clinical
  • resulting symptoms
  • immunosuppressive therapeutic
  • background paper

  • permanent tissue
  • occupational exposure
  • detect changes
  • exposed populations
  • identify persons

  • increased risk
  • markers discussed
  • brief history
  • assessment issued
  • cause asthma


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