Clinical Practice Guidelines Directions for a New Program (1990) / Chapter Skim
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Pages 133-134
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From page 133... ...
4 In the Netherlands, a screening program of single-view mammography every two years for women over age 35 was introduced in 1975.25 After seven years, this case-control study showed that mammography significantly reduced the risk of mortality from breast cancer in women 50 and over. A case-control study in Italy also reported a strong inverse relationship between mortality from breast cancer and mammographic screening in women aged 50 and older.26 More than 280,000 women in the United States were screened with a combination of clinical examination and mammography during the Breast Cancer Detection Demonstration Project.27 This demonstration project was not designed as a research study, however, and lacked a control group.
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From page 134... ...
4 Follow-up data from the HIP study suggest that women aged 4049 who receive periodic mammography and clinical examination may experience a reduction of about 25% in breast cancer mortality, but the investigators and others have not found this difference to be statistically significant.22 32 Interpretations of statistical significance when analyzing these data are influenced by a number of factors, some of which include the definition of the 4049 age group (i.e., age at entry into study vs. age at diagnosis)
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