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Environmental Neurotoxicology (1992) / Chapter Skim
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7. Conclusions and Recommendations
Pages 123-128

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From page 123...
... 123 The committee concludes that neurotoxic effects can be caused by exposure to chemical agents in the environment. Environmental chemicals have been shown to cause neurotoxic effects in individual cases and in epidemics.
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From page 124...
... The estimate must be based on a combination of clinical, epidemiologic, and toxicologic studies coupled with the techniques of quantitative risk assessment. The committee concludes that additional biologic markers for the assessment of subclinical neurotoxic effects are needed.
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From page 125...
... The committee recommends that existing in vitro test methods be exploited more extensively than at present to identity and analyze the mechanisms of neurotoxic action at cellular levels. ~ To that end, it is necessary to undertake a program to test the relationship between in vitro and in viva findings and between animal and human results for a set of welldefined substances.
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From page 126...
... The committee concludes that uniform clinical definitions of neurotoxic disorders are needed, to provide a common basis for reporting by physicians. The committee recommends that improved disease reporting be supported by the dissemination of information on neurotox~c illnesses to physicians and other health professionals, to increase their awareness of environmental neurotox~city as a possible explanation of specific illnesses or sets of symptoms.
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From page 127...
... The committee recommends that researchers make complete, original data sets available to other investigators to facilitate full exploration of relationships and development of risk-assessment models. The committee further recommends that to improve the assessment of the human risks associated with exposure to possible neurotoxic agents, risk-assessment methods that capture the complexities of the neurologic response, including dose-time-response relationships, multiple outcomes, and integrated organ systems be developed.
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Key Terms

  • neurotoxic effects
  • prospective studies
  • clinical studies
  • neurotoxicity testing
  • chemical agents

  • quantitative risk
  • psychiatric disorders
  • vitro test
  • environmental origin
  • psychiatric disease

  • neurotoxic agents
  • environmental chemicals
  • subclinical neurotoxic
  • testing strategy
  • putative biologic

  • product safety
  • chemical substances
  • cause subclinical
  • increasing evidence
  • major obstacle

  • objective testing
  • quantitative information
  • doses predict
  • providing data
  • permit tests

  • toxicologic studies
  • psychiatric dysfunction
  • designs permit
  • hypothesized quantitative
  • neurotoxic illnesses


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