Malaria Obstacles and Opportunities (1991) / Chapter Skim
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Pages 289-296
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Glossary A actin a protein that is a major constituent of cell microfilaments. adjuvant a compound, injected as a mixture with an antigen, that serves to intensity the immune response.
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antigenic variation see antigenic diversity. apical complex a group of organelles, thought to be involved in the red blood cell invasion process, at the apical (tip)
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DDT 1,1,1-trichloro-2,2-bis(p -chlorophenyl) ethane or chlorophenothane, a pesticide.
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exflagellation the formation of microgametes by extrusion of nuclear material into peripheral processes of gametocyte cytoplasm. These processes resemble flagella.
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low levels, resulting in a population that generally has little or no immunity hypoglycemia an abnormally low level of sugar in the blood, which may result in shaking, cold sweats, hypothermia, headache, and potentially convulsions and coma. IgA Immunoglobulin A; a class of immunoglobulin found in external body secretions such as saliva, tears, and sweat, and on the surface of cell membranes.
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marginal cost the extra cost for an extra unit of output. merozoite the stage of the parasite, in the human host, that infects the red blood cells.
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recombinant vaccine a vaccine prepared by recombinant DNA technology in which a a host organism (expression vector) is directed to synthesize specific molecules as the result of insertion of DNA segments from another organism (such as the malaria parasite)
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concept is to use those portions of the organism that are immunogenic, leaving out those that produce pathologic manifestations. synthetic vaccine a vaccine manufactured by biochemical means, to simulate the immunogenic portions of the organism against which the vaccine is being prepared tandem repeats duplications of tandem combinations.
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