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Afterword on Research Needs
Pages 206-207

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From page 206...
... Many of the population-based epidemiologic studies are too small or have inadequate lengths of follow-up to have a reasonable chance of detecting true adverse effects, unless these effects are large or occur promptly and consistently after vaccination. If research capacity and accomplishment in this field are not improved, future reviews of vaccine safety will be similarly handicapped.
From page 207...
... The availability and introduction of new forms of pertussis vaccine, for example, could offer valuable opportunities for comparison of vaccine safety as well as efficacy. The committee is not in a position to make specific recommendations, but its experience points to fresh possibilities and to the need for such a review.

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