Skip to main content

Adverse Effects of Pertussis and Rubella Vaccines (1991) / Chapter Skim
Currently Skimming:

Appendix C: Animal Models for the Study of Whooping Cough and the Testing of Vaccine Materials
Pages 333-336

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 333...
... pertussis, and rabbits carry the organism for months without showing signs of disease (Ashworth et al., 1982; Weiss and Hewlett, 1986~. Most of the information about pertussis gained from animal models has come from the study of mice.
Read the entire page →
From page 334...
... Despite these obvious differences from the infection in humans, protection in this model has correlated with vaccine efficacy in humans (Medical Research Council, 1959; Standfast, 19581. STANDARDIZED ANIMAL TESTS OF VACCINE MATERIALS The intracerebral mouse protection test (Kendrick et al., 1947, 1949)
Read the entire page →
From page 335...
... These vagaries further illustrate the difficulty of generalizing to humans the results obtained from studies in animals. A sensitive assay for the particularly important toxin PT and for anti-PT has been developed by using Chinese hamster ovary (CHO)
Read the entire page →
From page 336...
... Journal of Biological Standardization 13:61-66. Hewlett EL, Sauer KT, Myers GA, Cowell JL, Guerrant RL.
Read the entire page →

Key Terms

  • whooping cough
  • animal models
  • mouse protection
  • pertussis toxin
  • virulence factors

  • pertussis vaccine
  • chinese hamster
  • hamster ovary
  • protection tests
  • medical journal

  • human disease
  • protection test
  • adenylate cyclase
  • british medical
  • outer membrane

  • membrane protein
  • ovary cells
  • weight gain
  • extracytoplasmic adenylate
  • filamentous hemagglutinin

  • vaccine materials
  • carefully engineered
  • mutant deficient
  • mutant strains
  • gain test

  • strains raise
  • bacterial strain
  • poor weight
  • vaccine hsf
  • intracerebral mouse


    • This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
    More information on Chapter Skim is available.