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From page 355... ... , 162 Anaphylaxis, 40, 47-48, 177, 283 animal studies, 148-149, 150 case reports, 146 controlled studies, 146-148 human studies, 146-148 pertussis vaccine and, 8, 71, 146, 149-150, 172, 175 Angioneurotic edema, 150, 172 Animal experiments, 4, 39-41, 59, 83, 118, 347 Read the entire page →
From page 356... ... , 4, 161, 162, 163, 164, 283-284 Attributable fraction, 284 Attributable risk, 35, 42, 284 encephalopathy, 104, 114-115, 117, 323 See also Relative risk Autism, 4, 284 diagnosis, 152 epidemiology, 151 human studies, 151-152 Autopsy, 129, 145, 146, 149 B bacteremia, 145 Bacterial endotoxin, 40, 149 Bacterial meningitis, 70, 82 Bias, 3, 35, 50, 56, 138, 206, 284 "information bias," 45 in NCES data, 44~5 "recall bias," 72, 103 Biologic plausibility, 3, 4, 54, 59 anaphylaxis, 47-48, 150 arthritis, 195, 196 erythema multiforme, 47-48, 154 hemolytic anemia, 48 radiculoneuritis, 199 sudden infant death syndrome, 140 thrombocytopenic pu~pura, 201 Birth trauma, 66 Birth weight, 126, 127, 136 Blacks arthritis incidence, 188 diabetes incidence, 159-160 sudden infant death syndrome and, 126, 127 Bordet, Jules, 320 Bordetella avium, 14 Bordetella bronchiseptica, 14, 334 Bordetella parapertussis, 14 Bordetella pertussis, 9, 10, 11, 12, 14 17, 320 animal studies, 14, 40, 115-116, 333-335 Read the entire page →
From page 357... ... , 323-324 Children arthritis incidence, 188, 190, 191, 195 aseptic meningitis, 83 autism, 151 encephalopathy and seizures, 88, 106, 116 Guillain-Barre syndrome, 155 hypsarrhythmia, 67 Read the entire page →
From page 358... ... , 200 Computed tomography, 66 Confidence intervals, 58, 136, 139, 341-342 Confounding factors, 3, 33, 35, 50, 101, 103-104, 206 Controlled epidemiologic studies, 3, 4, 38-39, 41-46, 59, 285, 300 anaphylaxis, 146-148 arthritis, 39, 189-190, 194, 196 aseptic meningitis, 84-85 encephalopathy, 41, 42, 43, 52, 107115, 117, 118 hypsarrhythmia, 80-82 infantile spasms, 69-76, 78-79 juvenile diabetes, 160 learning disabilities, 163-164 protracted crying and screaming, 166-168 Reye syndrome, 170 INDEX shock, 173-177 sudden infant death syndrome, 130-140 Controlled Study Review Form, 312319 Convulsions, 71, 87, 88, 98, 101, 106. See also Afebrile seizures; Febrile seizures; Seizures Convulsive disorder, 107 Cortical atrophy, 66 Cost-benefit analysis, 1-2, 38 Coulter, Harris L., vii, 324 Cross-sectional surveys, 45 Cyanosis, 172, 176 Cytomegalovirus, 154 D Data sources, 293-294 de Baillou, Guillaume, 9-10 Denmark, 66, 69-70, 76-77 Developmental abnormalities, 104, 105 Diagnosis arthritis, 195 aseptic meningitis, 84 autism, 152 encephalopathy, 113, 117 Guillain-Barre syndrome, 154-155, 156 infantile spasms, 66, 74 learning disabilities, 164 pertussis, 11 rubella, 20 Diagnostic and Statistical Manual of Mental Disorders (APA) Read the entire page →
From page 359... ... , 192 Epidemiologic studies, 8, 33, 34, 35, 206, 337 359 resolution, 56-58 See also Controlled epidemiologic studies Epidemiology arthritis, 188 aseptic meningitis, 83 autism, 151 encephalopathy, 90 erythema multiforme, 152 Guillain-B arre syndrome, 155 hemolytic anemia, 158 hypsarrhythmia, 77 infantile spasms, 65-66 juvenile diabetes, 159-160 learning disabilities, 162-163 peripheral mononeuropathy, 156 pertussis, 9-14, 40 radiculoneuritis, 197-199 Reye syndrome, 170 rubella, 19-22 sudden infant death syndrome, 125, 126-127 thrombocytopenia, 178 thrombocytopenic purpura, 199 Epilepsy, 65, 88, 90, 95 pertussis vaccination and, 2, 70, 9394, 98, 106, 107, 108, 118, 118n.3, 173 Epstein-Barr virus, 154 Error types, 57 Erythema multiforme, 46, 285 case reports, 152-153 epidemiology, 152 human studies, 152-153 pertussis vaccination and, 4, 47-48, 153-154 Experimental studies, 3, 8, 39, 206207, 285 F Family income, 126 Faroe Islands, 18, 320-321 Febrile convulsions, 72 Febrile seizures, 2, 87-88, 90 meta-analysis of data, 52, 115 pertussis vaccination and, 70, 94, 98 Read the entire page →
From page 360... ... F., 326 Hill, A B., 52 Hiro, Y., 22-23, 326-327 Histamine, 16, 144, 147-148, 153 Hives, 150 Human immunodeficiency virus, 154 Human studies, 4, 38-39, 59, 206-207, 300 anaphylaxis, 146-148 arthritis, 189-194, 329 aseptic meningitis, 84-85 autism, 151-152 encephalopathy, 91-115, 117 erythema multiforme, 152-153 Guillain-Barre syndrome, 155 hemolytic anemia, 158-159 hypsarrhythmia, 80-82 infantile spasms, 67-76 juvenile diabetes, 160 learning disabilities, 163-164 peripheral mononeuropathy, 156-157 protracted crying and screaming, 165-168 radiculoneuritis, 198 Reye syndrome, 170-171 shock, 172-176 sudden infant death syndrome, 128140 thrombocytopenia, 178 thrombocytopenic purpura, 200 Hyperactivity, 161, 162, 163, 173, 286 Hyperimmunization, 148 Hyperinsulinemia, 16 Hyperkinesis, 162 Hypoglycemia, 16, 93, 160 Hypotonia, 91 Hypotonic diplegia, 67 Hypotonic, hyporesponsive episodes (HHE) Read the entire page →
From page 361... ... codes anaphylaxis, 147 arthritis, 193 aseptic meningitis, 84 autism, 151 encephalopathy, 94 epilepsy, 95 erythema multiforme, 153 Guillain-Barre syndrome, 155 hemolytic anemia, 158-159 hypotonic, hyporesponsive episodes, 173 361 infantile spasms, 69 juvenile diabetes, 160 learning disabilities, 163 . peripheral mononeuropathy, 157 radiculitis, 198 Reye syndrome, 171 screaming, 166 seizures, 94 sudden infant death syndrome, 129 thrombocytopenia, 178 thrombocytopenic purpura, 200 International Symposium on Pertussis, 105, 326 Intracerebral mouse protection test, 334-335 Intracranial hemorrhage, 66 Intranasal mouse protection test, 116, 335 IQ scores, 97, 162, 175 Islet-activating protein (pertussis toxin) Read the entire page →
From page 362... ... , 48-49, 287, 300 anaphylaxis, 147, 150 arthritis, 193 aseptic meningitis, 84 autism, 151 encephalopathy and seizures, 93, 94 erythema multiforme, 153-154 Guillain-Barre syndrome, 155-156 hemolytic anemia, 158-159 hyperactivity and learning disability, 163, 164 infantile spasms, 69 juvenile diabetes, 160 peripheral mononeuropathy, 157 protracted crying and screaming, 166 radiculitis, 198 Reye syndrome, 171 shock, 173 sudden infant death syndrome, 129 thrombocytopenia, 178-179 thrombocytopenic purpura, 200-201 Monitoring System for Illness Following Immunization (MSIFI) , 322 Mortality, 1 anaphylaxis, 145 encephalopathy, 88 pertussis, 13, 14 pertussis vaccination, 18-19, 71, 8990, 91, 93, 116, 148, 320-321, 322 pneumonia, 92 rubella, 21 shock, 172 sudden infant death syndrome, 125, 126-127, 128, 140, 141 Motor retardation, 87, 165-166, 168, 177 Mouse weight gain test, 116, 166-167, 335 Read the entire page →
From page 363... ... , 17, 320 Nicolle, Charles, 17, 320 Noncontrolled clinical studies, 46, 287 North West Thames Study, 71, 76, 97, 146-147, 167, 175, 324 Null hypothesis, 35, 57 Nutritional deficiencies, 12 o Odds ratio, 34, 43-44, 51-52, 53, 287, 337-338 infantile spasms, 76-77 neurologic illness, 113 sudden infant death syndrome, 136, 138, 341, 342-344 Optic neuritis, 198 Otitis media, 193n.1 p Paralysis, 100 Paralytic syndromes, 112 Parapertussis, 14, 287 Paresis, 156-157 Paresthesias, 197, 198 Parke-Davis & Company, 321 Parkman, Paul D., 22, 23, 327 Pathologic mechanisms, 206 Perinatal hypoxia, 66 Peripheral mononeuropathy, 4, 46, 287 Read the entire page →
From page 364... ... , 16, 94, 147, 149, 160, 334, 335 Pertussis vaccine, 1, 13, 39, 44, 45-46, 57, 207, 289 acellular vaccines, 17-18, 39 adsorbed vaccines, 54, 55, 98, 167, 289, 347-348 animal models, 40, 41, 333-335 development of, 17-18, 320-326, 334-335 exposure, 3 toxicity, 166-167 whole-cell vaccines, 17, 18, 39, 54, 55 Pertussis vaccine, adverse events, v, vi, vii, 2, 4-8, 18-19, 32, 38, 46, 50n.3, 52, 323, 348 anaphylaxis, 8, 71, 146-150, 172, 175 aseptic meningitis, 4, 70, 83-86 autism, 4, 152 encephalopathy, 8, 47, 87, 88, 89-90, 91-118, 344-345, 348 erythema multiforme, 4, 47-48, 153154 Guillain-Barre syndrome, 4, 155-156 hemolytic anemia, 4, 48, 158-159 hypsarrhythmia, 8, 67, 77-82, 98 infantile spasms, 8, 57, 67-77, 100, 101, 103, 112 juvenile diabetes, 4, 160-161 learning disabilities, 4, 163-164 peripheral mononeuropathy, 4, 157 protracted crying and screaming, 4, 8, 87, 165-169 INDEX Reye syndrome, 8, 170-171 shock, 8, 87, 98, 172-177 sudden infant death syndrome, 8, 33, 46, 51, 52, 128-141, 322, 339, 340, 342 thrombocytopenia, 8, 178-179 "Pertussis vaccine-induced encephalopathy," 87, 117 Pervasive developmental disorders, 151 Petechiae, 125, 178, 199, 200 Physicians, 49 Platelet-activating factor, 144 Platelet counts, 177-178, 199, 200 Pneumonitis, 125 Polio, 321 Polio vaccine, oral (OPV) , 68, 71, 84, 93, 153, 155, 158, 163, 170, 171, 178, 321 Polyneuritis, 21, 154 Polyneuropathy, 154, 155, 197 Polyradiculitis, 154 Positron tomography, 66 Power calculations, 37, 56-58, 337-340 Pregnancy antibody transmission in, 145 complications, 151 intrauterine infections, 66 rubella transmission in, 19, 20, 22, 327 Primates, 333 Progressive necrologic deterioration, 67 Proteins, 149, 150 cerebral spinal fluid, 155 Pertussis toxin, 16 Protracted crying and screaming case reports, 165-166 controlled studies, 166-168 human studies, 165-168 Pertussis vaccination and, 4, 8, 87, 165, 168-169 Psychomotor retardation, 65, 67 Public Health Service (PHS) Read the entire page →
From page 365... ... See Relative risk Rubella (German measles) , 288, 327 arthritis following, 187, 191, 193 365 complications, 20 diagnosis, 20 epidemiology, 19-22 radiculoneuritis following, 197, 199 thrombocytopenic purpura, 199 Rubella panencephalitis, 21 Rubella vaccine, 1, 22, 39, 55, 289 animal models, 40, 41 development of, 22-23, 326-329 exposure, 3 Rubella vaccine, adverse events, v, vi, vii, 2, 8, 23-24, 32, 38, 46, 52, 71, 328 arthritis, 8, 21, 24, 55, 187, 188-197, 328, 329 radiculoneuritis, 8, 55, 198-199 thrombocytopenic purpura, 8, 55, 200-201 Rubella virus, 21, 22, 23 S Salk polio vaccine, 321 Sauer, Louis, 19, 321 Seizure disorders, 90, 108 Seizures, 42, 43, 87-88, 177 aseptic meningitis and, 82 infantile spasms and, 65, 66, 67, 75 76 in NCES data, 100, 101, 103, 105, 106, 112 pertussis vaccination and, 87, 93-94, 95-97, 118 See also Afebrile seizures; Febrile seizures Shock, 16, 116, 145, 146, 171-172 case reports, 172-173, 177 controlled studies, 173-177 human studies, 172-176 pertussis vaccination and, 8, 87, 98, 172, 176-177 Sleep apnea, 126 Smallpox vaccine, 68 Social Security Act (1965) Read the entire page →
From page 366... ... , 12, 13 arthritis incidence, 188 Sweden, 80, 323 DPT vaccination in, 17, 19, 39, 54, Switzerland, 23 69, 128, 321, 348 Synovial membrane infection, 194, 196 Guillain-Barre syndrome incidence, 155 T Tachycardia, 172 Tasaka, S., 22-23, 326-327 Task Force Report on Pertussis, 324 Tennessee Department of Health, 128 Tetanus vaccine, 54, 150, 154, 156, 157, 158 Thrombocytopenia, 21, 46, 177-178, 288 case reports 178 epidemiology, 178 human studies, 178 pertussis vaccination and, 8, 178-179 Thrombocytopenic purpura, 46, 178, 288 case reports, 55, 200 epidemiology, 199 human studies, 200 rubella vaccination and, 8, 55, 200 201 Tokyo Women's Medical College, 68 Toxemia, 115, 333 "Toxic effects," 89 United States, 322 infantile spasms incidence, 66 juvenile diabetes incidence, 159 pertussis incidence, 13, 14 Reye syndrome incidence, 170, 171 rubella incidence, 22, 23, 327 rubella vaccination in, 23, 24, 55, 199, 328 sudden infant death syndrome deaths, 128-129, 140 U.S. Congress, v, 325, 328 U.S. Read the entire page →
From page 367... ... . V11 Vasculitis, 148 Viral encephalitis, 82, 103, 105, 107 367 W Waxman, Henry, 324 Wechsler Intelligence Scale for Children, 97, 175 Weller, Thomas H., 22, 23, 327 West syndrome, 65 Whites arthritis incidence, 188 juvenile diabetes in, 159-160 pertussis incidence, 13 Whooping cough. Read the entire page →

From page 355...

... , 162 Anaphylaxis, 40, 47-48, 177, 283 animal studies, 148-149, 150 case reports, 146 controlled studies, 146-148 human studies, 146-148 pertussis vaccine and, 8, 71, 146, 149-150, 172, 175 Angioneurotic edema, 150, 172 Animal experiments, 4, 39-41, 59, 83, 118, 347

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From page 356...

... , 4, 161, 162, 163, 164, 283-284 Attributable fraction, 284 Attributable risk, 35, 42, 284 encephalopathy, 104, 114-115, 117, 323 See also Relative risk Autism, 4, 284 diagnosis, 152 epidemiology, 151 human studies, 151-152 Autopsy, 129, 145, 146, 149 B bacteremia, 145 Bacterial endotoxin, 40, 149 Bacterial meningitis, 70, 82 Bias, 3, 35, 50, 56, 138, 206, 284 "information bias," 45 in NCES data, 44~5 "recall bias," 72, 103 Biologic plausibility, 3, 4, 54, 59 anaphylaxis, 47-48, 150 arthritis, 195, 196 erythema multiforme, 47-48, 154 hemolytic anemia, 48 radiculoneuritis, 199 sudden infant death syndrome, 140 thrombocytopenic pu~pura, 201 Birth trauma, 66 Birth weight, 126, 127, 136 Blacks arthritis incidence, 188 diabetes incidence, 159-160 sudden infant death syndrome and, 126, 127 Bordet, Jules, 320 Bordetella avium, 14 Bordetella bronchiseptica, 14, 334 Bordetella parapertussis, 14 Bordetella pertussis, 9, 10, 11, 12, 14 17, 320 animal studies, 14, 40, 115-116, 333-335

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From page 357...

... , 323-324 Children arthritis incidence, 188, 190, 191, 195 aseptic meningitis, 83 autism, 151 encephalopathy and seizures, 88, 106, 116 Guillain-Barre syndrome, 155 hypsarrhythmia, 67

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From page 358...

... , 200 Computed tomography, 66 Confidence intervals, 58, 136, 139, 341-342 Confounding factors, 3, 33, 35, 50, 101, 103-104, 206 Controlled epidemiologic studies, 3, 4, 38-39, 41-46, 59, 285, 300 anaphylaxis, 146-148 arthritis, 39, 189-190, 194, 196 aseptic meningitis, 84-85 encephalopathy, 41, 42, 43, 52, 107115, 117, 118 hypsarrhythmia, 80-82 infantile spasms, 69-76, 78-79 juvenile diabetes, 160 learning disabilities, 163-164 protracted crying and screaming, 166-168 Reye syndrome, 170 INDEX shock, 173-177 sudden infant death syndrome, 130-140 Controlled Study Review Form, 312319 Convulsions, 71, 87, 88, 98, 101, 106. See also Afebrile seizures; Febrile seizures; Seizures Convulsive disorder, 107 Cortical atrophy, 66 Cost-benefit analysis, 1-2, 38 Coulter, Harris L., vii, 324 Cross-sectional surveys, 45 Cyanosis, 172, 176 Cytomegalovirus, 154 D Data sources, 293-294 de Baillou, Guillaume, 9-10 Denmark, 66, 69-70, 76-77 Developmental abnormalities, 104, 105 Diagnosis arthritis, 195 aseptic meningitis, 84 autism, 152 encephalopathy, 113, 117 Guillain-Barre syndrome, 154-155, 156 infantile spasms, 66, 74 learning disabilities, 164 pertussis, 11 rubella, 20 Diagnostic and Statistical Manual of Mental Disorders (APA)

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From page 359...

... , 192 Epidemiologic studies, 8, 33, 34, 35, 206, 337 359 resolution, 56-58 See also Controlled epidemiologic studies Epidemiology arthritis, 188 aseptic meningitis, 83 autism, 151 encephalopathy, 90 erythema multiforme, 152 Guillain-B arre syndrome, 155 hemolytic anemia, 158 hypsarrhythmia, 77 infantile spasms, 65-66 juvenile diabetes, 159-160 learning disabilities, 162-163 peripheral mononeuropathy, 156 pertussis, 9-14, 40 radiculoneuritis, 197-199 Reye syndrome, 170 rubella, 19-22 sudden infant death syndrome, 125, 126-127 thrombocytopenia, 178 thrombocytopenic purpura, 199 Epilepsy, 65, 88, 90, 95 pertussis vaccination and, 2, 70, 9394, 98, 106, 107, 108, 118, 118n.3, 173 Epstein-Barr virus, 154 Error types, 57 Erythema multiforme, 46, 285 case reports, 152-153 epidemiology, 152 human studies, 152-153 pertussis vaccination and, 4, 47-48, 153-154 Experimental studies, 3, 8, 39, 206207, 285 F Family income, 126 Faroe Islands, 18, 320-321 Febrile convulsions, 72 Febrile seizures, 2, 87-88, 90 meta-analysis of data, 52, 115 pertussis vaccination and, 70, 94, 98

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From page 360...

... F., 326 Hill, A B., 52 Hiro, Y., 22-23, 326-327 Histamine, 16, 144, 147-148, 153 Hives, 150 Human immunodeficiency virus, 154 Human studies, 4, 38-39, 59, 206-207, 300 anaphylaxis, 146-148 arthritis, 189-194, 329 aseptic meningitis, 84-85 autism, 151-152 encephalopathy, 91-115, 117 erythema multiforme, 152-153 Guillain-Barre syndrome, 155 hemolytic anemia, 158-159 hypsarrhythmia, 80-82 infantile spasms, 67-76 juvenile diabetes, 160 learning disabilities, 163-164 peripheral mononeuropathy, 156-157 protracted crying and screaming, 165-168 radiculoneuritis, 198 Reye syndrome, 170-171 shock, 172-176 sudden infant death syndrome, 128140 thrombocytopenia, 178 thrombocytopenic purpura, 200 Hyperactivity, 161, 162, 163, 173, 286 Hyperimmunization, 148 Hyperinsulinemia, 16 Hyperkinesis, 162 Hypoglycemia, 16, 93, 160 Hypotonia, 91 Hypotonic diplegia, 67 Hypotonic, hyporesponsive episodes (HHE)

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From page 361...

... codes anaphylaxis, 147 arthritis, 193 aseptic meningitis, 84 autism, 151 encephalopathy, 94 epilepsy, 95 erythema multiforme, 153 Guillain-Barre syndrome, 155 hemolytic anemia, 158-159 hypotonic, hyporesponsive episodes, 173 361 infantile spasms, 69 juvenile diabetes, 160 learning disabilities, 163 . peripheral mononeuropathy, 157 radiculitis, 198 Reye syndrome, 171 screaming, 166 seizures, 94 sudden infant death syndrome, 129 thrombocytopenia, 178 thrombocytopenic purpura, 200 International Symposium on Pertussis, 105, 326 Intracerebral mouse protection test, 334-335 Intracranial hemorrhage, 66 Intranasal mouse protection test, 116, 335 IQ scores, 97, 162, 175 Islet-activating protein (pertussis toxin)

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From page 362...

... , 48-49, 287, 300 anaphylaxis, 147, 150 arthritis, 193 aseptic meningitis, 84 autism, 151 encephalopathy and seizures, 93, 94 erythema multiforme, 153-154 Guillain-Barre syndrome, 155-156 hemolytic anemia, 158-159 hyperactivity and learning disability, 163, 164 infantile spasms, 69 juvenile diabetes, 160 peripheral mononeuropathy, 157 protracted crying and screaming, 166 radiculitis, 198 Reye syndrome, 171 shock, 173 sudden infant death syndrome, 129 thrombocytopenia, 178-179 thrombocytopenic purpura, 200-201 Monitoring System for Illness Following Immunization (MSIFI) , 322 Mortality, 1 anaphylaxis, 145 encephalopathy, 88 pertussis, 13, 14 pertussis vaccination, 18-19, 71, 8990, 91, 93, 116, 148, 320-321, 322 pneumonia, 92 rubella, 21 shock, 172 sudden infant death syndrome, 125, 126-127, 128, 140, 141 Motor retardation, 87, 165-166, 168, 177 Mouse weight gain test, 116, 166-167, 335

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From page 363...

... , 17, 320 Nicolle, Charles, 17, 320 Noncontrolled clinical studies, 46, 287 North West Thames Study, 71, 76, 97, 146-147, 167, 175, 324 Null hypothesis, 35, 57 Nutritional deficiencies, 12 o Odds ratio, 34, 43-44, 51-52, 53, 287, 337-338 infantile spasms, 76-77 neurologic illness, 113 sudden infant death syndrome, 136, 138, 341, 342-344 Optic neuritis, 198 Otitis media, 193n.1 p Paralysis, 100 Paralytic syndromes, 112 Parapertussis, 14, 287 Paresis, 156-157 Paresthesias, 197, 198 Parke-Davis & Company, 321 Parkman, Paul D., 22, 23, 327 Pathologic mechanisms, 206 Perinatal hypoxia, 66 Peripheral mononeuropathy, 4, 46, 287

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From page 364...

... , 16, 94, 147, 149, 160, 334, 335 Pertussis vaccine, 1, 13, 39, 44, 45-46, 57, 207, 289 acellular vaccines, 17-18, 39 adsorbed vaccines, 54, 55, 98, 167, 289, 347-348 animal models, 40, 41, 333-335 development of, 17-18, 320-326, 334-335 exposure, 3 toxicity, 166-167 whole-cell vaccines, 17, 18, 39, 54, 55 Pertussis vaccine, adverse events, v, vi, vii, 2, 4-8, 18-19, 32, 38, 46, 50n.3, 52, 323, 348 anaphylaxis, 8, 71, 146-150, 172, 175 aseptic meningitis, 4, 70, 83-86 autism, 4, 152 encephalopathy, 8, 47, 87, 88, 89-90, 91-118, 344-345, 348 erythema multiforme, 4, 47-48, 153154 Guillain-Barre syndrome, 4, 155-156 hemolytic anemia, 4, 48, 158-159 hypsarrhythmia, 8, 67, 77-82, 98 infantile spasms, 8, 57, 67-77, 100, 101, 103, 112 juvenile diabetes, 4, 160-161 learning disabilities, 4, 163-164 peripheral mononeuropathy, 4, 157 protracted crying and screaming, 4, 8, 87, 165-169 INDEX Reye syndrome, 8, 170-171 shock, 8, 87, 98, 172-177 sudden infant death syndrome, 8, 33, 46, 51, 52, 128-141, 322, 339, 340, 342 thrombocytopenia, 8, 178-179 "Pertussis vaccine-induced encephalopathy," 87, 117 Pervasive developmental disorders, 151 Petechiae, 125, 178, 199, 200 Physicians, 49 Platelet-activating factor, 144 Platelet counts, 177-178, 199, 200 Pneumonitis, 125 Polio, 321 Polio vaccine, oral (OPV) , 68, 71, 84, 93, 153, 155, 158, 163, 170, 171, 178, 321 Polyneuritis, 21, 154 Polyneuropathy, 154, 155, 197 Polyradiculitis, 154 Positron tomography, 66 Power calculations, 37, 56-58, 337-340 Pregnancy antibody transmission in, 145 complications, 151 intrauterine infections, 66 rubella transmission in, 19, 20, 22, 327 Primates, 333 Progressive necrologic deterioration, 67 Proteins, 149, 150 cerebral spinal fluid, 155 Pertussis toxin, 16 Protracted crying and screaming case reports, 165-166 controlled studies, 166-168 human studies, 165-168 Pertussis vaccination and, 4, 8, 87, 165, 168-169 Psychomotor retardation, 65, 67 Public Health Service (PHS)

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From page 365...

... See Relative risk Rubella (German measles) , 288, 327 arthritis following, 187, 191, 193 365 complications, 20 diagnosis, 20 epidemiology, 19-22 radiculoneuritis following, 197, 199 thrombocytopenic purpura, 199 Rubella panencephalitis, 21 Rubella vaccine, 1, 22, 39, 55, 289 animal models, 40, 41 development of, 22-23, 326-329 exposure, 3 Rubella vaccine, adverse events, v, vi, vii, 2, 8, 23-24, 32, 38, 46, 52, 71, 328 arthritis, 8, 21, 24, 55, 187, 188-197, 328, 329 radiculoneuritis, 8, 55, 198-199 thrombocytopenic purpura, 8, 55, 200-201 Rubella virus, 21, 22, 23 S Salk polio vaccine, 321 Sauer, Louis, 19, 321 Seizure disorders, 90, 108 Seizures, 42, 43, 87-88, 177 aseptic meningitis and, 82 infantile spasms and, 65, 66, 67, 75 76 in NCES data, 100, 101, 103, 105, 106, 112 pertussis vaccination and, 87, 93-94, 95-97, 118 See also Afebrile seizures; Febrile seizures Shock, 16, 116, 145, 146, 171-172 case reports, 172-173, 177 controlled studies, 173-177 human studies, 172-176 pertussis vaccination and, 8, 87, 98, 172, 176-177 Sleep apnea, 126 Smallpox vaccine, 68 Social Security Act (1965)

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From page 366...

... , 12, 13 arthritis incidence, 188 Sweden, 80, 323 DPT vaccination in, 17, 19, 39, 54, Switzerland, 23 69, 128, 321, 348 Synovial membrane infection, 194, 196 Guillain-Barre syndrome incidence, 155 T Tachycardia, 172 Tasaka, S., 22-23, 326-327 Task Force Report on Pertussis, 324 Tennessee Department of Health, 128 Tetanus vaccine, 54, 150, 154, 156, 157, 158 Thrombocytopenia, 21, 46, 177-178, 288 case reports 178 epidemiology, 178 human studies, 178 pertussis vaccination and, 8, 178-179 Thrombocytopenic purpura, 46, 178, 288 case reports, 55, 200 epidemiology, 199 human studies, 200 rubella vaccination and, 8, 55, 200 201 Tokyo Women's Medical College, 68 Toxemia, 115, 333 "Toxic effects," 89 United States, 322 infantile spasms incidence, 66 juvenile diabetes incidence, 159 pertussis incidence, 13, 14 Reye syndrome incidence, 170, 171 rubella incidence, 22, 23, 327 rubella vaccination in, 23, 24, 55, 199, 328 sudden infant death syndrome deaths, 128-129, 140 U.S. Congress, v, 325, 328 U.S.

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From page 367...

... . V11 Vasculitis, 148 Viral encephalitis, 82, 103, 105, 107 367 W Waxman, Henry, 324 Wechsler Intelligence Scale for Children, 97, 175 Weller, Thomas H., 22, 23, 327 West syndrome, 65 Whites arthritis incidence, 188 juvenile diabetes in, 159-160 pertussis incidence, 13 Whooping cough.

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Index Pages 355-367

Index
Pages 355-367