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2 Ethyl Phosphorodichloridate Acute Exposure Guideline Levels
Pages 42-65

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From page 42...
... Both the document and the AEGL values were then reviewed by the National Research Council (NRC) Committee on Acute Exposure Guideline Levels.
From page 43...
... Although the AEGL values represent threshold concentrations for the general public, including susceptible subpopulations, such as infants, children, the elderly, persons with asthma, and those with other illnesses, it is recognized that individuals, subject to idiosyncratic responses, could experience the effects described at concentrations below the corresponding AEGL. SUMMARY Ethyl phosphorodichloridate is a colorless liquid used as an intermediate in the preparation of the pesticide ethoprop.
From page 44...
... . Extrapolating a 4-h value to a 10-min AEGL-3 value is justified because no deaths were noted in male rats exposed to ethyl phosphorodichloridate at 20,900 ppm or in female rats exposed at 16,700 ppm for 10 min (Bayer 1983)
From page 45...
... 2.2. Nonlethal Toxicity Human nonlethal toxicity data were not found.
From page 46...
... Clinical signs observed in all treatment groups during the 2 h immediately following exposure included labored breathing, gasping, decreased activity, anogenital staining, and moist rales
From page 47...
... Rats in the 6.16-ppm group exhibited labored breathing, rales, fine tremors, and nasal discharge for a "few days" after exposure; however, the animals fully recovered during the second week post-exposure prior to sacrifice. "Significant" weight loss was noted one week following exposure in the 66- and 134-ppm groups; however, surviving rats showed some recovery prior to sacrifice.
From page 48...
... Rats killed after the 14-day observation period exhibited slightly bloated lungs at the higher concentrations. Specific necropsy findings associated with the different concentrations were not reported.
From page 49...
... . No lethality was reported in rats exposed to ethyl phosphorodichloridate at 16,700-20,900 ppm for 10 min; whereas, 90% mortality was noted in rats exposed at 10,700-14,400 ppm for 30 min and 100% mortality was noted in rats exposed at 12,000-13,700 ppm for 1 h (Bayer 1983)
From page 50...
... 14,400 30 min Male 5/5 Day 1 Significant weight loss throughout 14-day follow-up period in single 10,700 30 min Female 4/5 Days 3-4 surviving female. 13,700 1h Male 5/5 Day 1 During exposure: audible oral noises; cramped walking; ocular 12,000 1h Female 5/5 Days 1-3 and nasal irritation.
From page 51...
... It reportedly reacts with water to produce hydrogen chloride fumes, and may also produce fumes of phosphoric acid when heated (HSDB 2002)
From page 52...
... 5.2. Animal Data Relevant to AEGL-1 No animal data relevant to derivation of AEGL-1 values for ethyl phosphorodichloridate were available.
From page 53...
... . Extrapolating from a 4-h study duration to the 10-min AEGL-3 value is justified because no deaths were noted in male rats exposed to ethyl phosphorodichloridate at 20,900 ppm or in female rats exposed at 16,700 ppm for 10 min (Bayer 1983)
From page 54...
... . Because those fumes are irritating and corrosive, they may contribute to or be responsible for the irritation observed after exposure to ethyl phosphorodichloridate; however, the relative contribution of these decomposition products to the toxicity of the parent compound is unknown, as is the rate of decomposition.
From page 55...
... 2001. Standing Operating Procedures for Developing Acute Exposure Guideline Levels for Hazardous Chemicals.
From page 56...
... Attachment in Letter from Mobay Corporation, Pittsburg, PA, to U.S. EPA Submitting Toxicology Study on Ethylesterdichloride, Dated 12/31/90.
From page 57...
... . Extrapolating from the 4-h point of departure to the 10-min AEGL-3 value is justified because no deaths were noted in male rats exposed to ethyl phosphorodichloridate at 20,900 ppm or in female rats exposed at 16,700 ppm for 10 min (Bayer 1983)
From page 58...
... background have been estimated at a boundary point, or have been specified by the user, and do not appear in the correlation matrix.) Parameter Estimates Variable Estimate Standard error Intercept -12.0173 2.35981 Slope 2.6604 0.526262 NA: indicates that this parameter has hit a bound implied by some inequality constraint and thus has no standard error.
From page 59...
... Goodness of Fit Scaled Estimated Dose probability Expected Observed Size Residual 0.0000 0.0000 0.000 0 20 0 37.0000 0.0080 0.159 0 20 -0.4006 61.0000 0.1399 1.399 2 10 0.5477 75.0000 0.2977 5.954 4 20 -0.9556 90.0000 0.4817 9.633 12 20 1.059 143.0000 0.8822 17.643 17 20 -0.4462 355.0000 0.9998 19.997 20 20 0.05588 Chi-square = 2.70; DF = 5; P-value = 0.7465. Benchmark Dose Computation Specified effect = 0.05 Risk Type = Extra risk Confidence level = 0.95 BMD = 49.3439 BMDL = 37.9523 Probit 1 0.8 Fraction Affected 0.6 0.4 0.2 0 BMDL BMD 0 50 100 150 200 250 300 350 dose FIGURE B-1 Probit model with 0.95 confidence level.
From page 60...
... Attachment in Letter from Mobay Corporation to U.S. EPA Submitting Toxicology Study on Ethylesterdichloride, Dated 12/31/90.EPA Document No.
From page 61...
... . Extrapolating from a 4-h point of departure to a 10-min AEGL-3 value is justified because no deaths were noted in male rats exposed to ethyl phosphorodichloridate at 20,900 ppm or in female rats exposed at 16,700 ppm for 10 min (Bayer 1983)
From page 62...
... 62 Acute Exposure Guideline Levels APPENDIX D CATEGORY PLOT FOR ETHYL PHOSPHORODICHLORIDATE TABLE D-1 Category plot of animal toxicity data on ethyl phosphorodichloridate compared with AEGL values.
From page 63...
... . Rat 1 66 60 SL Labored breathing, gasping, decreased activity, rales, tremors, weight loss, mortality 8/10 (Rhone-Poulenc, Inc.
From page 64...
... . Rat 1 90 240 SL Severe ocular and nasal irritation, disturbed behavior, severe respiratory signs, mortality 12/20 (Bayer 1983)
From page 65...
... . Rat 1 14,400 30 3 Severe ocular and nasal irritation, disturbed behavior, severe respiratory signs, weight loss, mortality 5/5 (Bayer 1983)


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