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5 Epidemiologic Studies: Compendium of New Publications
Pages 128-144

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From page 128... ... In this chapter and later chapters, epidemiologic studies are organized into categories according to the populations being studied (Vietnam veterans, occupational populations other than Vietnam veterans, and nonoccupational populations affected by environmental exposures) or by study design (case-control) Read the entire page →
From page 129... ... (Design information on studies of new populations that involve single health outcomes is provided in the various health-outcomes chapters.) For presentation of the background information, the study populations are arranged into categories on the basis of whether they are composed of Vietnam veterans, occupationally exposed workers, or environmentally exposed individuals or were assembled according to a case-control approach focused on particular health outcomes. Read the entire page →
From page 130... ... Study Citation Design Having Results Reported Population Studies of Vietnam Veterans None Occupational Studies Kamel et Case- Pesticides, ALS AHS al., 2012 control herbicides, 2,4-D, (nested) 2,4,5-T, dicamba Environmental Studies Buck Cross- anti-estrogenic PCBs Menstrual cycles Women without Louis et sectional (correspond to dl reproductive problems al., 2011 PCBs) Read the entire page →
From page 131... ... Case-Control Studies Band et Case- 2,4-D, MCPA, Prostate cancer British Columbia al., 2011 control dicamba farmers Bonefeld- Case- Sum dl PCBs, Breast cancer Inuit women from Jorgensen control AHR-TEQs Greenland sampled et al., 2011 2000–2003 Cai et al., Case- Dioxins, furans, all Endometriosis Japanese women 2011 control dl-PCBs, TEQ in undergoing diagnostic peritoneal fluid and laparoscopy for serum infertility enrolled from October 2004 to March 2007 Gallagher Case- dl PCBs 118, 156, Melanoma Study participants et al., 2011 control total dl PCBs in were recruited using serum a population-based British Columbia Cancer Registry Lv et al., Case- Occupational MDS Shanghai, China 2011 control exposure to herbicides [marginal] Postuma et Case- Occupational REM sleep behavior Cases drawn from al., 2012 control herbicide exposure, disorder (prognostic seven centers non-occupational sign of PD and only as specific dementia) Read the entire page →
From page 132... ... lymphomas NOTE: 2,4-D, 2,4-dichlorophenoxyacetic acid; 2,4,5-T, 2,4,5-trichlorophenoxyacetic acid; AHR, aryl hydrocarbon receptor; AHS, Agricultural Health Study; ALS, amyotrophic lateral sclerosis; dl, dioxinlike; HL, Hodgkin lymphoma; MCPA, 2-methyl-4-chlorophenoxyacetic acid; MDS, myelodysplastic syndrome; NHL, non-Hodgkin lymphoma; PCB, polychlorinated biphenyl; PCDD, polychlorinated dibenzo-p-dioxin; PCDF, polychlorinated dibenzofuran; REM, rapid eye movement; TEQ, total toxic equivalent. scriptions and critiques of the designs of the studies are provided in the sections of the report that discuss the results related to particular health outcomes. Read the entire page →
From page 133... ... For the sake of completeness, the discussions of specific health outcomes and the associated cumulative-results tables in Chapters 7–13 include references to publications discussed in previous VAO reports and to new publications. In drawing its conclusions, the committee combined the evidence in new publications and the evidence synthesized in the most recent update (Update 2010) Read the entire page →
From page 134... ... Occupational Studies None Environmental Studies Chang et Cross- Serum PCDD/F TEQ Insulin resistance Taiwan, 1,449 nonal., 2011a sectional diabetic residents around closed PCP factory Chang et Cross- Serum PCDD/F TEQ CVD Taiwan, 914 residents al., 2011b sectional without CVD around closed PCP factory Chang et Cross- Serum PCDD/F Blood chemistries Taiwan, workers from al., 2012 sectional TEQ, also [Indirect evidence -- closed PCP factory vs consideration of diet more like biologic residents vs general as source plausibility] population Lee et al., Nested dl-PCBs 105, 118, Diabetes CARDIA cohort 2010 case-control 156, 157, 167 in serum Lee et al., Nested dl-PCBs 105, 118, Obesity, CARDIA cohort 2011a case-control 156, 157, 167 in dyslipedemia, insulin participants; study serum resistance subjects recruited at baseline in 1985–1986 and followed for 20 yrs Lee et al. Read the entire page →
From page 135... ... 1 mo before conception, 1st trimester, or 2nd– 3rd trimester NOTE: AO, Agent Orange; CARDIA, Coronary Artery Risk Development in Young Adults cohort; CVD, cardiovascular disease; dl, dioxin-like; HT, hypertension; NBDPS, National Birth Defects Prevention Study; PCB, polychlorinated biphenyl; PCDD, polychlorinated dibenzo-p-dioxin; PCDF, polychlorinated dibenzofuran; PCP, pentachlorophenol; PIVUS, Prospective Investigation of the Vasculature in Uppsala Seniors; POP, persistant organic pollutant; TCDD, 2,3,7,8-tetrachlorodibenzop-dioxin; TEQ, total toxic equivalent; VV, Vietnam veteran. Read the entire page →
From page 136... ... Study Citation Design Results Reported Population Studies of Vietnam Veterans None Occupational Studies Andreotti et Cohort Dicamba and BMI Focus on BMI at AHS (licensed al., 2010 as factors for colon enrollment and pesticide applicators cancer [marginal] incidence of various and spouses) Read the entire page →
From page 137... ... Study Citation Design Results Reported Population Koutros et al., Nested 2,4,5-T; 2,4-D; Prostate cancer AHS (licensed 2010b, 2011; case-control 2,4,5-TP; dicamba incidence pesticide applicators) ; Barry et al., 1993–2003 interaction between 2011, 2012 [most complete dose pesticide use and response info in SNPs (in metabolic Koutros et al., 2011] Read the entire page →
From page 138... ... Lambertino et Cohort Σdl PCBs Uterine leiomyoma Great Lakes Fish al., 2011 Consumption Study Mocarelli et Cohort Serum Sperm quality Seveso; sons born al., 2011 concentrations of and reproductive (1977–1984) to TCDD hormones in dioxin-exposed offspring mothers Su et al., Cohort TEQs for PCBs, Reproductive Taiwanese Mother2012 PCDD/Fs development and-Child Study; followup to 8 yrs of age Tsukimori et Cohort Dioxin, furan, Birth weight (by sex Yusho mothers and al., 2012b and PCB TEQs of infant) Read the entire page →
From page 139... ... propionic acid; AHS, Agricultural Health Study; AML, acute myeloid leukemia; BMI, body mass index; CLL, chronic lymphocytic leukemia; CML, chronic myeloid leukemia; CNS, central nervous system; COI, chemical of interest; dl, dioxin-like; DLBCL, diffuse large B-cell lymphoma; DLC, dioxin-like compound; DNA, deoxyribonucleic acid; FL, follicular lymphoma; GI, gastrointestinal; HD, Hodgkin disease; hpCDD, heptachlorodibenzo-p-dioxin; IARC, International Agency for Research on Cancer; IHD, ischemic heart disease; MCL, mantle cell lymphoma; MCPA, 2-methyl-4-chlorophenoxyacetic acid; MM, multiple myeloma; MZL, marginal zone lymphoma; NHANES, National Health and Nutrition Examination Survey; NHL, non-Hodgkin lymphoma; NIOSH, National Institute of Occupational Safety and Health; OCDD, octachlorodibenzo-p-dioxin; PCB, polychlorinated biphenyl; PCDD, polychlorinated dibenzo-p-dioxin; PCDF, polychlorinated dibenzofuran; PCP, pentachlorophenol; SLL, small lymphocytic lymphoma; SNP, single-nucleotide polymorphism; STS, soft-tissue sarcoma; SWHS, Seveso Women's Health Study; TCDD, 2,3,7,8-tetrachlorodibenzo-p-dioxin; TEQ, total toxic equivalent; UMHS, Upper Midwest Health Study. not available for the entire cohort, such as data on individual serum TCDD concentrations and personal information that can be used to adjust for confounders of concern. Read the entire page →
From page 140... ... 2010. Body mass index, agricultural pesticide use, and cancer incidence in the Agricultural Health Study cohort. Read the entire page →
From page 141... ... 2011. Associations of fat mass and lean mass with bone mineral density differ by levels of persistent organic pollutants: National Health and Nutrition Examination Survey 1999–2004. Read the entire page →
From page 142... ... 2011b. Polychlorinated biphenyls and organochlorine pesticides in plasma predict development of type 2 diabetes in the elderly: The prospective investigation of the vasculature in Uppsala seniors (PIVUS) Read the entire page →
From page 143... ... 2011. Maternal exposure to polychlorinated biphenyls and the secondary sex ratio: An occupational cohort study. Read the entire page →
From page 144... ... 2012. The Upper Midwest Health Study: A case-control study of pesticide applicators and risk of glioma. Read the entire page →

From page 128...

... In this chapter and later chapters, epidemiologic studies are organized into categories according to the populations being studied (Vietnam veterans, occupational populations other than Vietnam veterans, and nonoccupational populations affected by environmental exposures) or by study design (case-control)

5 Epidemiologic Studies: Compendium of New Publications Pages 128-144

5 Epidemiologic Studies: Compendium of New Publications
Pages 128-144