Epidemiology in Military and Veteran Populations Proceedings of the Second Biennial Conference, March 7, 1990 (1991) / Chapter Skim
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Dioxins and Dibenzofurans in Adipose Tissue of U.S. Vietnam Veterans and Controls
Dioxins and Dibenzofurans in Adipose Tissue of U.S. Vietnam Veterans and Controls
Pages 67-80
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From page 67... ...
The geometric mean (+ standard deviation) dioxin levels in adipose tissue for Vietnam veterans, non-Vietnam veterans and civilian controls were 11.7 (+ 1.7)
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From page 68... ...
Many Vietnam veterans believe that they were heavily exposed to Agent Orange and that the exposure Is responsible for health problems such as skin rashes, rare types of cancer, and birth defects of their children. Since 1979, two hundred thousand Vietnam veterans have come to Department of Veterans Affairs (VA)
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From page 69... ...
reported that current serum dioxin levels of Army Vietnam combat troops did not differ significantly from those of non-Vietnam veterans and that dioxin levels in Vietnam veterans did not increase with increased exposure levels estimated from military records.9 This study was criticized on the basis that blood specimens taken almost 20 years after exposure could not represent what happened in Vietnam and that veterans selected for the study were limited to Army enlisted men who served in only one geographic region of Vietnam.~° The purpose of our study was twofold: (1) to determine if a group of individuals with military service in Vietnam have significantly higher levels of dioxin in adipose tissue than either a similar group of nonVietnam veterans or civilian peers, and (2)
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From page 70... ...
, and location of the individual's unit in Vietnam in relation to recorded Agent Orange spray. Ground troops in Vietnam might have had a higher probability of contact with Agent Orange than other Vietnam veterans due to the nature of their military operations.
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From page 71... ...
Army and Joint Services Environmental Support Group identified and documented an additional 6 million liters of herbicide sprayed mainly by Army personnel around the perimeter of base camps, fire bases, airbases and other fixed military installations. The opportunity for Agent Orange exposure was determined in two ways: an individual's company was ever located either within 2 kilometers (km)
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From page 72... ...
Factors considered a priori as covariates were age, adipose tissue sample collection year, race, and body mass index A regression model specific to Vietnam veterans included such covariates as military occupation, calendar year of tour in Vietnam, geographic region in Vietnam, time of and distance from recorded Agent Orange spray, and adipose tissue sample collection year. All statistical tests were conducted at the .05 level of significance.
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From page 73... ...
The 95% confidence limits for a mean dioxin difference between Vietnam veterans and civilian controls were -1.59 and 1.31. Stepwise linear regression analysis for 36 Vietnam veterans indicated that Vietnam service characteristics could account for only 14% of the variation in dioxin levels (p = 0.3)
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From page 74... ...
In a study by Kahn et al.,7 of 10 Vietnam veterans with heavy potential for exposure to Agent Orange (e.g. Ranch Hand personnel, Army Chemical Corps specialists)
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From page 75... ...
troops were heavily exposed to dioxin in Vietnam. Furthermore, none of the surrogate measures of Agent Orange exposure based on military service characteristics was associated with the dioxin levels in adipose tissue of Vietnam veterans.
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From page 76... ...
JAMA 1988; 259: 3533-3535 7. Kahn PC, Gochfeld M, Nygren M, et al: Dioacins and dibenzofurans in blood and adipose tissue of Agent Orange exposed Vietnam veterans and matched controls.
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From page 77... ...
in planning for the study is greatly appreciated.
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From page 78... ...
78 a 3 ~ Fly cn ILL 85 z , c rim ~ in, o o z o ~ ~ z U)
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From page 79... ...
90 days / 8 KM no 16 11.8 1.5 yes 19 11.8 1.8 a Standard deviation b Military Occupation Specialty Code (MOSC) c Missing Military Region information for one veteran d Missing information on time and distance from recorded herbicide spray for one veteran due to unknown unit location 79
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From page 80... ...
IPOSE TISSUE BY MILITARY SERVICE STATUS, IN PG/G OF THE TOTAL EXTRACTABLE LIPID (PPT) Status Chemicals Vietnam Non-Vietnam Civilians Veterans Veterans Dioxins 2378-TCDD 13.4 (36~*
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