First Symposium on Chemical-Biological Correlation, May 26-27, 1950 (1951) / Chapter Skim
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The Biological Codex
The Biological Codex
Pages 133-140
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From page 133... ...
THE BIOLOGICAL CODES R.L. Beard The Connecticut Agricultural Experiment Station New Haven, Connecticut
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From page 134... ...
Thus there is opportunity for expressing two hundred and seventy-six different ideas. Of these, two hundred and eleven have been utilized, which represent subdivisions of the following major considerations: Taxonomic groups of microorganisms and plants Physiologic actions on plants Taxonomic groups of invertebrates Physiologic action on invertebrates Population control of microorganisms Population control of invertebrates Chemotherapeutic action against parasitic infections Enzymes Carcinogenic and carcinoclastic action General physiologic actions pertaining to microorganisms, plants, and animals Taxonomic groups of vertebrates Morphology and pharmacology of vertebrates The unit represented by the punched card is the chemical compound.
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From page 135... ...
Technique Size of inoculum in chemotherapeutic studies Route and manner of administration of inoculum Route and manner of administration of test chemical Route and manner of administration of secondary chemical Part treated Method of expressing dosage Concentration component of dosage Quantity component of dosage Time component of dosage Frequency of dose Duration of action Time of evaluation Criterion of response Slope of the dosage-response curve Physical state of the compound when applied Physical state of the compound when response is read Presence of conditioning agents Properties of the compound studied; indication of additional information
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From page 136... ...
On the other hand, this observation would be represented according to the Detailed Code by a punched card recording the information as follows: Indole-butyric acid Induces Tissue development (in the) Shoot (as an)
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From page 137... ...
To understand how the cards can be used as an aid in answering questions it should be explained that data sheets, on which may be found information abstracted from original papers, are filed according to the test chemical. As mentioned before, the punched cards describing the chemistry of test chemicals (Chemical Cards)
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From page 138... ...
" From the Biological Card file based on the Primary organ system those cards dealing with the Nervous System can be hand selected, and from the Chemical rotated file those cards dealing with the desired structural groups can be hand selected. These groups of cards then can be handled as follows: Hand select Collate Sort Collate Nervous system C4N C3NS C3NO CN(Z)
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From page 139... ...
The systems outlined above were not designed to replace the thinking process, nor can they be expected to yield a completed manuscript ready for publication. They were designed to serve as a research tool to facilitate experimental work and to provide leads toward new investigations.
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