First Symposium on Chemical-Biological Correlation, May 26-27, 1950 (1951) / Chapter Skim
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A Demonstration of the Use of the CBCC System in the Field of Antithyroid Compounds
A Demonstration of the Use of the CBCC System in the Field of Antithyroid Compounds
Pages 155-164
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A DEMONSTRATION OF THE USE OF THE CBCC SYSTEM IN THE FIELD OF ANTITHYROID COMPOUNDS George W Anderson Chemotherapy Division, Stamford Research Laboratories American Cyanamid Company, Stamford, Connecticut
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However, revision of the detailed CBCC biological code caused sufficient delay that not all of the antithyroid literature could be abstracted and the data coded, punched and sorted for a complete • tudy. The results to be described here were nevertheless sufficient to indicate that the CBCC system is workable, and can be used conveniently to answer specific questions in the antithyroid field.
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Later, the number of cards increased considerably as the work of abstracters and coders flowed in, and all of these were used in Procedure II. Results are given in Table I
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G) , for rats 39 Procedure II (simplified from 1; used on final data)
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This illustrates that information on punches cards can be extracted by various procedures. When a large number of cards is involved, the actual running time of the machine is important; a skilled operator can reduce it to a minimum using an efficient pre-filing system.
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The other two were not as good as thiouracil but have not been definitely rated. TABLE 2 ANSWERS TO GROUP I QUESTIONS Question 1 Compounds tested relative to Thiouracil .
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These were then reassembled by the collator in order of the CBCC numbers. Thus, this stack was ready for comparison with the cards indicating tests in man, which were obtained by an operation on all the residue cards of Procedure II.
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The procedure was to compare the cards obtained from Questions 1, 3 and 10 with the rotated chemical cards which were made up from all the basic antithyroid group including active and inactive compounds. You will recall that the rotated cards are obtained by duplicating each chemical card in such a way that each chemical group in turn appears first in the sequence of chemical code designations.
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As the quantity of data grows, the value of the work done by the CBCC will increase. Perhaps some day we shall call it indispens able
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