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Recommendations for the Prevention of Lead Poisoning in Children (1976) / Chapter Skim
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Appendix C: CPSC-Supplied Animal Studies
Pages 29-36

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From page 29...
... AGE Age is an important factor in both the susceptibility of the brain to the effects of lead and the intestinal absorption rate of lead. Young animals, particularly suckling animals, are more susceptible to nervous system injury than juvenile or adult animals.5,13,25,26 In addition, the intestinal absorption rate of lead is significantly higher in suckling animals (see Appendix B)
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From page 30...
... Measures of Internal Dose and Effect - All studies provided blood lead values for the control period and at various intervals during the study period. The control blood lead levels (mean approximately 10 yg Pb/dl)
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From page 31...
... Their studies did show that lead in paint is about 1/3 - 1/4 'as well absorbed as inorganic lead salts. Thus, the New York study on lead octoate is corroborated and the two studies form the basis for estimating that the paint matrix reduces absorption by a factor of 3-4.
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From page 32...
... 60 yg Pb/dl in whole blood with positive roentgenographic evidence of lead storage in the bones and a median fecal lead output of 1.ll mg Pb/day. Thus, Gage and Litchfield's estimate of a dangerous level of lead intake was based on a fecal lead output 40 times greater than that found in children with positive evidence of long-term lead exposure and blood lead levels in a range associated with the appearance of neurologic damage.
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From page 33...
... -- > OH in r^ 8 • a to C W cd QQ • O 01 jj fc 3» 1 1 O rH lf> -a 01 U CO U C^| cd co o 03 3 e £ q 0)
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From page 34...
... 0 -~lpOO M Chip Siz 200 " 2 11 19.4 1.95 20 13 < 50 p 500 " 26 136.1 12.43 20 13 100 0.06 2 All dok^s contained 100 0.28 2 0.07 5Z Lead 100 «.'••'• 2 6 100 2.C 2 6 Diet Frd for 48 hrc Lead Arcta'e Lead Acrtatc 2p,«te»t cont.ol 100 b 4 4 100 7 4 100 26 200 24 500 25 10.000 2 • 4 20 Intravenous 2 6 Lead Octo.llc »cnd Ottoalc in <'..in "oil Klxrd in torn Oil 100 40".
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From page 35...
... Authors report Immediate depression in all animals where blood-lead levels reached a steady state concentration of 50 ug Z or more. /Proposed the measurement as pre dictive determinant to lead exposure/ Free »rythrocyte rfqrphvjrin (FE?
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From page 36...
... ot determined ot determined ot determined No paint data Control mean total lead .51 ug Octoate 500-lOOOu 2.38 ug < 50 u 4.30 Mg Chromate 300-1000 u 2.18 ug < 50 u 3.35 uS No point data. a Table III Comparison of Lead Accumulation in Tissues of Weanling Rats.Lead acetate Lead acetate in oil Dietary Kidney Blood UR lead/ 100 ml Bone Total lead iig Concentra 1 1 on Total lead jig 0.02Z 11.28 56.31 5.87 11.52 51.81 6.08 0.02Z 20.25 97.5 9.03 22.75 93.3 11.53 a Data from Barltrop.
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Key Terms

  • significant difference
  • lead octoate
  • animals fed
  • intestinal absorption
  • fecal lead

  • lead levels
  • lead output
  • york study
  • paint lead
  • lead compounds

  • lead content
  • total lead
  • mean fecal
  • absorption rate
  • fed lead

  • study lead
  • lead concentration
  • lead dose
  • lead concentrations
  • lead poisoning

  • lead acetate
  • experimental animals
  • blood choline
  • significant increase
  • paint matrix

  • paint formulations
  • significant findings
  • choline concentration
  • dietary deficiencies
  • suckling animals


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