Symposium on the Role of the Vestibular Organs in Space Exploration (1970) / Chapter Skim
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USE OF DRUGS IN THE PREVENTION OF MOTION SICKNESS
USE OF DRUGS IN THE PREVENTION OF MOTION SICKNESS
Pages 101-108
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From page 101... ...
Drugs which block parasympathetic or stimulate sympathetic activity are most effective. Drugs such as the phenothiazines, phenoxybenzamine, or meprobamate, which reduce sympathetic activity, appear to increase susceptibility to motion sickness.
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From page 102... ...
Phenoxybenzamine HC1 and thiethylperazine maleate in the usual doses, as well as a triple dose of the latter, were found to reduce the subjects' tolerance to the stressful Coriolis accelerations. Trimethobenzamide HC1 in a triple dose and meprobamate ranked just below the placebo level, while a single dose of the former was effective just above that level.
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From page 103... ...
These 3I0 200 I90 I80 170 i/i id 60 Z uj 150 5 -1 § SM0 O S 130 2 g •^ i20 LJ O or 90 « s ao y S 70 P H 60 50 > 40 [ ^ I0 t 0 -o -20 -30 -4O -SO EFFECTIVENESS OF ANTIMOTION SICKNESS DRUGS IN PREVENTING MOTION SICKNESS IN 50 SUBJECTS EXPOSED ON 500 OCCASIONS IN A ROTATING ENVIRONMENT USING THE "DIAL TEST" 3 1 End point. Uokiiie III t Mean pIacebo ieveI 5 Stondardned pattern of head mo> •ments .
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From page 104... ...
The parasympatholytic class of anti-motionsickness drugs is represented in this study by scopolamine. This preparation, also known as hyoscine by the British, has had extensive testing and has proven to be the most effective drug in this classification, which includes a number of synthetic preparations and atropine.
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From page 105... ...
The results of our drug evaluation studies indicate that the effective drugs act by activating the central sympathetic activity or blocking the central parasympathetic activity. In this way, the autonomic activity during exposure to motion would be shifted toward the protective sympathetic reactions.
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From page 106... ...
D.; GRAYBIEL, A.; AND KENNEDY, R S.: A Comparison of Effectiveness of Some Antimotion Sickness Drugs Using Recommended and Larger Than Recommended Doses as Tested in the Slow Rotation Room.
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From page 107... ...
. We tested this compound in the Canadian Air Force on several search-and-rescue missions involving low flying in turbulent areas.
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