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Symposium on the Role of the Vestibular Organs in Space Exploration (1970) / Chapter Skim
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RESUME OF SESSIONS ON MOTION SICKNESS
Pages 117-122

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From page 117...
... Figure 4 is a phantom view of the medulla showing the spatial orientation of various components of the neurological mechanism responsible for coordinating the complex sequential pattern of vomiting. I will not dwell on the experimental evidence for localization of the brainstem "centers." We have concluded from our studies that organization and integration of the emetic response must be accomplished in the reticular formation and that the CTZ on the medullary surface serves solely as a sensory organ -- a chemical transducer, if you will -- for specific agents in the bloodstream as well as in the cerebrospinal fluid.
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From page 118...
... FIGURE 1. -- Egyptian lady vomiting. A review of the input-output relations of the emetic reflex follows: The chemoreceptor trigger zone is an input component sensitive to emetic substances in blood and cerebrospinal fluid.
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From page 119...
... This relates to a cat that resided in my laboratory, which we took one day to visit a country school in the rolling hills of New Hampshire. I was going to show the children some simple reflex responses to enliven my talk on the subject, "Your Brain Protects You." On our way to the school the cat vomited in the back seat of the car, which is not a very unusual occurrence on the roads of New Hampshire, except that this cat was one of our experimental animals possessing a lesion of the chemoreceptor trigger zone.
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From page 120...
... As a result of extensive investigative efforts we are faced with the fact that anti-motion-sickness drug efficacy bears no correlative relationship to other types of antiemetic drug activity. Thus, antiemetic drugs that are effective antagonists of substances that act on the CTZ are not effective in preventing motion sickness.
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From page 121...
... SESSION V Chairman: BO E GERNANDT INaval Aerospace Medical Institute
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Key Terms

  • chemoreceptor trigger
  • trigger zone
  • vomiting center
  • reticular formation
  • fourth ventricle

  • emetic reflex
  • emetic chemoreceptor
  • drug efficacy
  • reflex arc
  • phantom view

  • cerebrospinal fluid
  • vomiting figure
  • vomiting component
  • motion capable
  • emetic process

  • superficial chemoreceptor
  • output chemoreceptor
  • depicted vomiting
  • medullary emetic
  • vomiting mechanism

  • preventing motion
  • resulting emetic
  • emetic drug
  • emetic response
  • emetic substances

  • emetic stimuli
  • emetic effectiveness
  • emetic refractoriness
  • complete emetic
  • vomiting means


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