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Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic Interim Report (2013) / Chapter Skim
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Appendix B--Workshop Agenda
Pages 115-117

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From page 115...
... Environmental Protection Agency 9:40 am Mode of Action and Mechanism Identification and Implications for Low Dose Assessments Samuel Cohen, University of Nebraska Medical Center 10:05 am Interplay Between One-carbon Metabolism, Arsenic Metabolism and Epigenetics Mary Gamble, Columbia University 10:30 am BREAK 10:45 am Mode of Action for Lung and Cardiovascular Effects R Clark Lantz, University of Arizona 11:10 am Impact of In Utero and Whole Life Exposure and Implications for Dose Response Michael Waalkes, National Institute for Environmental Health Sciences 11:35 am Panel Discussion: Moderators: Aaron Barchowsky and Rebecca Fry 1.
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From page 116...
... 12:30 pm BREAK Probabilistic Dose–Response and Harmonization Approaches for Cancer and Noncancer Effects 1:30 pm  Lessons Learned from Lead and Particulate Matter Joel Schwartz, Harvard School of Public Health 2:00 pm  Extrapolation of Mode of Action Data to Dose–Response Modeling of Human Health End Points Harvey Clewell, The Hamner Institutes of Health Sciences 2:30 pm Panel Discussion: Moderators: Gary Ginsberg and Robert Wright Discussant: Daniel Axelrad, U.S. Environmental Protection Agency 1.
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From page 117...
... Question 2: Barbara Beck and Kate Sande 2a. EPA has been asked by stakeholders to explicitly include consideration of populations that may have increased susceptibility to the adverse effects from arsenic (e.g., life stages, genetics, pre-existing disease, and environmental stressors such as co-exposures and nutritional deficiencies)
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Key Terms

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  • low dose
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  • toxicological review

  • iris values
  • dose assessments
  • national toxicology
  • harvey clewell
  • nebraska medical

  • quantitative estimates
  • single toxicity
  • currently standard
  • available gene
  • assessment activities

  • break risk
  • joyce tsuji
  • probabilistic assessment
  • expression data
  • evidence integration

  • toxicology program
  • life exposure
  • clark lantz
  • recommend epa
  • dose mechanisms

  • maximum time
  • assessment approaches
  • risk assessments
  • based dose
  • multiple risk


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