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1 Introduction
Pages 9-15

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From page 9...
... Controversy regarding this issue led the US Environmental Protection Agency (EPA) to review the evidence on NMDR curves and to request that the National Research Council conduct an independent scientific review of the draft of State of the Science Evaluation: Nonmonotonic Dose Responses as They Apply to Estrogen, Androgen, and Thyroid Path 9
From page 10...
... . Siince then, EPAA's Endocrrine Disruptor Screening Program has furthher developed tthe Tier 1 assaays and eng gaged in a validation processs intended to ennsure that the TTier 1 data wouuld be reliaable and reprooducible among laboratories..
From page 11...
... (2012) reviewed the extensive literature on NMDR relationships, and concluded that "fundamental changes in chemical testing and safety determination are needed to protect human health." In an editorial in Environmental Health Perspectives, the director of NIEHS cited that review and indicated that future research should be directed at answering the question of "which dose-response shapes should be expected from specific environmental chemicals and under what specific circumstances" (Birnbaum 2012)
From page 12...
... The working group adopted consensus definitions of four key terms for the SOTS evaluation: NMDRs, EDC, low-dose effect, and adverse effect. The definitions were:  NMDRs: "measured biological effects with dose response curves that contain a point of inflection where the slope of the curve changes sign at one or more points within the tested range" (EPA 2013)
From page 13...
... THE COMMITTEE'S TASK AND APPROACH Given the complex nature of NMDR curves exhibited by EDCs and their possible importance in interpreting toxicity testing and risk assessment, EPA asked the National Research Council to review the draft SOTS evaluation. In response to the request, the Research Council convened the Committee to Review EPA's Draft State of the Science Paper on Nonmonotonic Dose Response.
From page 14...
... 2013. Scientific opinion on the hazard assess ment of endocrine disruptors: Scientific criteria for identification of endocrine dis ruptors and appropriateness of existing test methods for assessing effects mediated by these substances on human health and the environment.
From page 15...
... Presentation at the First Meeting on Review of EPA's Draft Paper State of the Science on Nonomonotonic Dose Response, July 23, 2013, Washington, DC. UNEP/WHO (United Nations Environment Program/World Health Organization)


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