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Technological Challenges in Antibiotic Discovery and Development A Workshop Summary (2014) / Chapter Skim
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4 Challenges In Drug Delivery
Pages 19-22

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From page 19...
... THERAPEUTICS DESIGN Metabolic network analysis using microarray expression The first approach that J Rubén Morones-Ramírez dis- data showed that nanoparticulate silver was upregulating cussed in his presentation involved the use of synergistic iron metabolism, triggering a membrane stress response and antibiotic cocktails that include nanoparticulate silver as disrupting metabolic regulation.
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From page 20...
... coli discussed the results of an experiment in which a catheter produces a novel antifungal agent that enables it to have a colonized with biofilm-embedded Staphylococcus aureus growth advantage over Candida. Though efforts to isolate was exposed to vancomycin, linezolid, and daptomycin, at and identify this antifungal compound have eluded him so concentrations 5, 10, and 20 times the breakpoint minimum far, he believes that the concept of co-culturing microorgan- inhibitory concentration of each antibiotic.
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From page 21...
... mammalian proteins, is conserve across bac , ed cterial porous and is involved in two essentia gens, al This porous structure released levels of daptomycin that DISCUSSION remained 10 times higher than the breakpoint minimum 29 In response to a question about the toxicity of silver inhibitory concentration for over a week. Tests in animals nanoparticles, Morones-Ramírez said that silver is toxic with osteomyelitis showed that the xylitol plus daptomycin to mammals, but at much higher concentrations than for combination was highly effective at eliminating the Staphy- bacteria.
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From page 22...
... 2011. Small molecule inhibitors of Staphylococcus aureus RnpA alter cellular mRNA turn over, exhibit antimicrobial activity, and attenuate pathogenesis.
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Key Terms

  • staphylococcus aureus
  • bone cement
  • biofilm formation
  • nanoparticulate silver
  • cell membrane

  • antimicrobial agents
  • breakpoint minimum
  • antibiotic delivery
  • aureus biofilms
  • lococcus aureus

  • minimum inhibitory
  • drug delivery
  • local antibiotic
  • mechanistic understanding
  • inhibitory concentration

  • mark smeltzer
  • oxygen species
  • silver inhibitory
  • antimicrobial effect
  • antibiotic susceptibility

  • aureus isolated
  • bacterial peritonitis
  • bacterial pathogens
  • cell line
  • reactive cell

  • hepatic cell
  • bacterial load
  • thathylococcus aureus
  • bacterial urinary
  • antibiotas bone


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