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Technological Challenges in Antibiotic Discovery and Development A Workshop Summary (2014) / Chapter Skim
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1 Introduction and Overview
Pages 1-6

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From page 1...
... antibiotic development and the technological challenges and health care system. Studies have estimated that, in the United barriers to be overcome." States alone, antibiotic resistance adds $20 billion in excess direct health care costs, with additional costs to society for ORGANIZATION OF THE WORKSHOP SUMMARY lost productivity as high as $35 billion a year.
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From page 2...
... Common mechanisms of resistance include a change participants. As the workshop was limited in the time avail- in drug target, such as when a bacterial enzyme undergoes able to cover a very broad topic, it was therefore decided a structural change to eliminate a drug binding site, or the to cover only a subset of issues and questions facing the appearance of a drug-metabolizing enzyme, as in the case of current state of antibiotic discovery and development in KPC and NDM.
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From page 3...
... at ems an said, ibiotic of las resort, trea st atment overa all becomes ineffective once resistan reason s. The appea andof two specific en and development that are "getting in the way of good drugs." A majornce develops comprehensive arance sustainable research o nzymes in CRE – Klebsiellfinancial markets carbapenemase (KPC program feeding the pipeline with antimicrobial agents, is skepticism in the la pneumonia of the value of antibi- C)
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From page 4...
... In response to a question about whether new diagnostic It is important to keep in mind that toxicity can arise from technologies that can rapidly identify specific strains with many mechanisms, including off-target binding and poor specific resistance patterns could lead to better use of narrowspecificity. spectrum antibiotics, Aurigemma said that this was indeed After briefly reviewing the many known microbial a promising area of research that could have a significant targets for antibacterial development (Figure 1-2)
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From page 5...
... 2013. Antibiotic Resistance Threats in the United States 2013.
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Key Terms

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  • chemical libraries
  • technological challenges

  • infectious diseases
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  • workshop summary
  • novel antimicrobial

  • drug targets
  • rose aurigemma
  • natural antibacterial
  • growing threat
  • aurigemma noted

  • aurigemma explained
  • lactam ring
  • chapter recounts
  • various enzymes
  • reported confirmed

  • western europe
  • available antibiotic
  • overcoming antibiotic
  • ceftriax antibiotic
  • fundingem antibiotic

  • facing antibiotic
  • antibiotic world
  • report antibiotic
  • antibiotic developers
  • antibiotic classes


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