Review of the Styrene Assessment in the National Toxicology Program 12th Report on Carcinogens (2014) / Chapter Skim
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Appendix D: Literature Search Strategies Used in Support of the Committee's Independent Assessment of Styrene
Appendix D: Literature Search Strategies Used in Support of the Committee's Independent Assessment of Styrene
Pages 168-178
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The search resulted in 229 papers. National Research Council staff reviewed the titles and abstracts of all 229 results and excluded 184 as not relevant (see Figure D-1)
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The publication did not contain primary data. The publication did not include information sufficient to determine what experimental methods were used.
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The search terms are described in Box D-3 and a search tree representing the results is depicted in Figure D-3. National Research Council staff reviewed the titles and abstracts of the remaining 118 results and excluded 115 as not relevant.
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STUDIES OF MECHANISMS OF CARCINOGENESIS Genotoxicity and Mutagenicity The committee identified and evaluated relevant, publicly available, peerreviewed literature on the genotoxicity and associated mechanistic events that have been associated with exposure to styrene or styrene-7,8-oxide. Exclusion criteria for study relevance were defined and applied to the retrieved literature by reviewing the abstracts of the retrieved publications and then reviewing full
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Because there was not a specific section in the background document for styrene (NTP 2008) that discussed immunosuppression in detail, the committee undertook a broad search without any date limits (see Box D-5 and Figure D-5)
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Cytotoxicity The committee and National Research Council staff developed a search algorithm to identify relevant cytotoxicity studies that were published in PubMed (see Box D-6 and Figure D-6)
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This search identified a total of 217 references, 16 of which addressed animal studies of toxicity of styrene or its metabolites, including two reviews, and all of which had been identified in the previous searches. 118 Publications identified in the literature search for experimental animal studies 115 Publications excluded according to exclusion criteria 3 Publications were further evaluated using full text 3 Publications excluded as not relevant according to exclusion criteria 0 Publications identified as relevant and evaluated in Chapter 3 FIGURE D-3 Literature tree for search of studies relevant to experimental animals.
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144 Publications identified in the literature search for genotoxicity and mutagenicity studies 114 Publications removed according to exclusion criteria 30 Publications were further evaluated using full text 16 Publications removed as not relevant according to exclusion criteria +4 Publications +20 Publications 14 added from IARC added from Scott (1994a,b; 2002) and Preston (1994)
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233 Publications identified in the literature search for immunosuppression studies 214 Publications removed according to exclusion criteria 19 Publications were further evaluated using full text 0 Publications removed as not relevant according to exclusion criteria 19 Publications identified as relevant and evaluated in Chapter 3 FIGURE D-5 Literature tree for search of studies relevant to styrene immunosuppression.
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261 Publications identified in the literature search for cytotoxicity studies 247 Publications removed according to exclusion criteria 14 Publications were further evaluated using full text 0 Publications removed as not relevant according to exclusion criteria 14 Publications identified as relevant and evaluated in Chapter 3 FIGURE D-6 Literature tree for search of studies relevant to styrene cytotoxicity.
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:266-277. NRC (National Research Council)
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