Review of EPA's Integrated Risk Information System (IRIS) Process (2014) / Chapter Skim
Currently Skimming:
1 Introduction
1 Introduction
Pages 10-16
The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.
From page 10... ...
was signed into law; the House report (112-151) accompanying the act stated that "EPA shall incorporate, as appropriate, based on chemical-specific datasets and biological effects, the recommendations of Chapter 7 of the National Research Council's Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde into the IRIS process." To ensure that EPA adequately considers the NRC recommendations, Congress requested that NRC assess the scientific, technical, and process changes that EPA is making.
|
From page 11... ...
The NRC committee convened to conduct that task released its report in 2011. It identified problems similar to those expressed by earlier NRC committees and concluded that "the draft was not prepared in a consistent fashion; it lacks clear links to an underlying conceptual framework; and it does not contain sufficient documentation on methods and criteria for identifying evidence from epidemiologic and experimental studies, for critically evaluating individual studies, for assessing the weight of evidence, and for selecting studies for derivation of the RfCs and unit risk estimates " (NRC 2011, p.
|
From page 12... ...
. Release of NRC formaldehyde report April 2011 EPA announces commitment to July 2011 responding to NRC recommendations Congress directs EPA IRIS program to incorporate, as appropriate, NRC December 2011 recommendations into chemical assessments EPA provides Congress with progress report June 2012 on implementing NRC recommendations Kenneth Olden becomes director, EPA July 2012 National Center for Environmental Assessment EPA holds first stakeholder meeting to hear November 2012 views on needed improvements in IRIS EPA provides draft template, preamble, handbook, and chemical-specific examples to NRC January 2013 IRIS committee and the public First meeting of Chemical Assessment April 2013 Advisory Committee of the Science Advisory Board EPA provides IRIS committee with updates on improvements and additional chemical-specific July 2013 examples EPA announces additional improvements in IRIS August 2013 EPA holds systematic review workshop August 2013 FIGURE 1-1 Timeline of events since release of the NRC report, Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde.
|
From page 13... ...
A specific approach to summarize quantitatively somewhat more homogeneous information is often referred to as meta-analysis. TABLE 1-1 Materials Received from the US Environmental Protection Agency Document Content Date Received Part 1: Status of Implementation Status report on implementation January 30, 2013 of Recommendations IRIS toxicologic review template Preamble to IRIS toxicologic reviews Example of directions for contractors Information on Comment Tracker Database Information on scoping for IRIS assessments Draft handbook for IRIS assessment development Part 2: Chemical-Specific Examples Seven chemical-specific examples of implementation January 30, 2013 of various NRC recommendations EPA Fact Sheet Summary of enhancements of IRIS program July 31, 2013 E-mail from IRIS program director Responses to NRC committee inquiries August 20, 2013 Attachments: Tables documenting implementation of NRC recommendations from draft ammonia, trimethylbenzene, and benzo[a]
|
From page 14... ...
The meaning and use of WOE analysis are discussed further in Chapter 6 of this report. THE COMMITTEE, ITS TASK, AND ITS APPROACH The committee, which was convened, included experts in epidemiology, toxicology, doseresponse modeling, risk assessment, systematic review, and risk communication (see Appendix A for biographic information on the committee)
|
From page 15... ...
Environmental Protection Agency (EPA) for its Integrated Risk Information System (IRIS)
|
From page 16... ...
2011. Review of the Environmental Protection Agency's Draft IRIS Assessment of Formaldehyde.
|
Key Terms
This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More
information on Chapter Skim is available.