Review of EPA's Integrated Risk Information System (IRIS) Process (2014) / Chapter Skim
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Appendix B: Workshop Agenda on Weight of Evidence
Appendix B: Workshop Agenda on Weight of Evidence
Pages 144-149
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From page 144... ...
8:15 Introduction and Overview of Session Lisa Bero Member, Committee to Review the IRIS Process Professor, Department of Clinical Pharmacy University of California, San Francisco 8:25 Systematic Review of Animal Studies and Approaches for Characterizing Study Quality Malcolm MacLeod Professor of Neurology and Translational Neuroscience University of Edinburgh 8:40 Systematic Review of Human Studies and Approaches for Characterizing Study Quality Karen Robinson Associate Professor Medicine, Epidemiology, and Health Policy and Management Johns Hopkins Medical Institutions 144
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From page 145... ...
Consideration of application of mechanistic data to cancer and noncancer chemical risk assessment within IRIS assessments is of over arching interest. 10:30 Introduction and Overview of Session David Dorman Member, Committee to Review the IRIS Process Professor of Toxicology, College of Veterinary Medicine North Carolina State University 10:40 Use of High-Throughput and High-Data-Content Technologies in Chemical Risk Assessment Rusty Thomas Director, Institute for Chemical Safety Sciences The Hamner Institutes for Health Sciences 11:00 Panel Discussion of High-Throughput Data for Determining Mechanism or Mode of Action Panelists: David Schwartz, Chair of Medicine, Professor of Medicine and Immunology, University of Colorado; George Leikauf, Professor of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh; Rusty Thomas, Direc tor, Institute for Chemical Safety Sciences, The Hamner Institutes for Health Sciences; Joe Rodricks, Principal, ENVIRON; and Thomas Hartung, Professor and Doerenkamp Zbinden Chair for Evidence-based Toxicology, Director Center for Alternatives to Animal Testing, Johns Hopkins Bloomberg School of Public Health
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From page 146... ...
This session will address qualitative and quantitative strategies for integrating evidence of different types in human health risk assessments. 1:00 Introduction and Overview of Session Scott Bartell Member, Committee to Review the IRIS Process Associate Professor, Program in Public Health University of California, Irvine 1:10 Qualitative and Quantitative Methods for Integrating Evidence Duncan Thomas Professor and Verna Richter Chair in Cancer Research, Keck School of Medicine University of Southern California Panel Discussion on Integrating Various Data Panelists: Steve Goodman, Professor of Medicine and Epidemiology, Stanford University; Kristina Thayer, Director, Office of Health Assessment and Translation, National Toxi cology Program; Duncan Thomas, Professor and Verna Richter Chair in Cancer Research, Keck School of Medicine, University of Southern California; Tracey Woodruff, Professor and Director, Program on Reproductive Health and the Environment, University of Cali fornia, San Francisco; and Lauren Zeise, Deputy Director for Scientific Affairs, Office of Environmental Health Hazard Assessment, California EPA Key Questions Topic 1: Hypothetical mechanisms or modes of action have been proposed for some toxi cants, largely based on research in animal models.
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From page 147... ...
3:00 Introduction and Overview of Session Richard Scheines Member, Committee to Review the IRIS Process Professor and Head of Philosophy Department Carnegie Mellon University 3:10 The Role of Mechanism in Causal Assessments and the State of Bradford-Hill Steve Goodman Professor of Medicine and Epidemiology Stanford University 3:25 Application of Causal Methods to Assess Effects of Chemical Exposures in Practice Lauren Zeise Deputy Director for Scientific Affairs Office of Environmental Health Hazard Assessment California EPA 3:40 Comparing Weight-of-Evidence Frameworks for Causation Lorenz Rhomberg Principal Gradient 3:55 Panel Discussion with Speakers on Causal Methods Key Questions Should the approach to causal inference within EPA guidelines be revised? Are the long standing causal criteria still useful, given the range of evidence considered in IRIS assess ments?
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From page 148... ...
Savage University Professor of Statistics, Emeritus Carnegie Mellon University 9:45 How the Public Interprets Uncertainty Communication: Some Lessons from the IPCC David Budescu Anne Anastasi Professor of Psychometrics and Quantitative Psychology Fordham University 10:00 Panel Discussion on Uncertainty Panelists: Tim Lash, Professor, Rollins School of Public Health, Emory; Chris Frey, Dis tinguished University Professor, North Carolina State University; David Budescu, The Anne Anastasi Professor of Psychometrics and Quantitative Psychology, Fordham Univer sity; Jay Kadane, Leonard J Savage University Professor of Statistics, Emeritus, Carnegie Mellon University; and Thomas Wallsten, Professor, Department of Psychology, Universi ty of Maryland
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From page 149... ...
11:00 Introduction and Overview of Session Ann Bostrom Member, Committee to Review the IRIS Process Professor, Daniel J Evans School of Public Affairs University of Washington 11:15 Panel Discussion on Expert Judgment Panelists: Tim Lash, Professor, Rollins School of Public Health, Emory; Chris Frey, Dis tinguished University Professor, North Carolina State University; David Budescu, The Anne Anastasi Professor of Psychometrics and Quantitative Psychology, Fordham Univer sity; Jay Kadane, Leonard J
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