Acute Exposure Guideline Levels for Selected Airborne Chemicals Volume 17 (2014) / Chapter Skim
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Pages 414-428
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7 Trimethylacetyl Chloride1 Acute Exposure Guideline Levels PREFACE Under the authority of the Federal Advisory Committee Act (FACA)
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Trimethylacetyl Chloride 415 effects. However, the effects are not disabling and are transient and reversible upon cessation of exposure.
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416 Acute Exposure Guideline Levels durations and n = 1 when extrapolating to longer durations to derive values protective of human health (NRC 2001)
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Trimethylacetyl Chloride 417 2. HUMAN TOXICITY DATA No human toxicity data or odor threshold data on trimethylacetyl chloride were found.
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418 Acute Exposure Guideline Levels 3.4. Chronic Toxicity and Carcinogenicity No data on chronic toxicity or carcinogenicity of trimethylacetyl chloride were found.
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Trimethylacetyl Chloride 419 4.4.3. Time Scaling The concentration-time relationship for many irritant and systemically acting vapors and gases may be described by the equation Cn × t = k, where the exponent n ranges from 0.8 to 3.5 (ten Berge et al.
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420 Acute Exposure Guideline Levels 6.3. Derivation of AEGL-2 Values No suitable data that provided a point of departure for deriving AEGL-2 values for trimethylacetyl chloride were available.
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Trimethylacetyl Chloride 421 182 ppm from the mouse RD50 study [Hardy and Kieran 1992]
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422 Acute Exposure Guideline Levels 8.2. Other Standards and Guidelines There are no other exposure standards or guidelines for trimethylacetyl chloride.
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Trimethylacetyl Chloride 423 APPENDIX A DERIVATION OF AEGL VALUES FOR TRIMETHYLACETYL CHLORIDE Derivation of AEGL-1 Values Data are insufficient to derive AEGL-1 values for trimethylacetyl chloride. Therefore, AEGL-1 values are not recommended.
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424 Acute Exposure Guideline Levels Uncertainty factors: 10 for interspecies differences 10 for intraspecies variability Modifying factor: 3 for sparse database 10-min AEGL-3: 0.60 ppm (set equal to the 30-min AEGL-3 value)
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Trimethylacetyl Chloride 425 APPENDIX B ACUTE EXPOSURE GUIDELINE LEVELS FOR TRIMETHYLACETYL CHLORIDE Derivation Summary AEGL-1 VALUES Data were insufficient to derive AEGL-1 values for trimethylacetyl chloride. Therefore, AEGL-1 values are not recommended for trimethylacetyl chloride.
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From page 426... ...
426 Acute Exposure Guideline Levels Intraspecies: 10 Modifying factor: 3, because of the sparse database. Animal-to-human dosimetric adjustment: None Time scaling: Cn × t = k, with default values of n = 3 when extrapolating to shorter durations and n = 1 when extrapolating to longer durations to derive values protective of human health (NRC 2001)
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Trimeth hylacetyl Chloride 4427 PPENDIX C AP CATEGORY C PLOT FOR TRIMETHYL T LACETYL CH HLORIDE FIGUR RE C-1 Categorry plot of toxiccity data and A AEGL values ffor trimethylaceetyl chloridee.
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428 TABLE C-1 Data Used in the Category Plot for Trimethylacetyl Chloride Source Species Sex No. Exposures ppm Minutes Category Effect AEGL-2 0.20 10 AEGL AEGL-2 0.20 30 AEGL AEGL-2 0.16 60 AEGL AEGL-2 0.10 240 AEGL AEGL-2 0.07 480 AEGL AEGL-3 0.60 10 AEGL AEGL-3 0.60 30 AEGL AEGL-3 0.47 60 AEGL AEGL-3 0.30 240 AEGL AEGL-3 0.20 480 AEGL Eastman Kodak 1992 Rat 1 78 360 2 Rough coat, labored breathing, body weight loss.
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