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2 Genomics in Population-Based Data Collection: The Example of the National Health and Nutrition Examination Survey
Pages 5-8

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From page 5...
... The examination component consists of medical, dental, and physiological measurements, as well as laboratory tests administered by highly trained medical personnel. Findings from this survey are used to determine the prevalence of major diseases and risk factors for diseases.
From page 6...
... As Porter explained, NHANES seeks to report findings that are valid and obtained by a CLIA-certified laboratory.1 Reportable findings should have significant implications for a participant's health concerns, and a course of action to ameliorate or treat the concerns should be readily available, both of which are in line with recommendations from the Presi 1 CLIA refers to regulations established by federal Clinical Laboratory Improvement Amendments; see http://www.cms.gov/Regulations-and-Guidance/Legislation/CLIA/ index.html? redirect=/clia/ [June 2014]
From page 7...
... The NHANES program consulted with review boards and ethicists about how to proceed, and the upshot, Porter explained, was the concept of "binning" the genome, shown in Figure 2-1. Gene variants could be sorted into buckets or bins, with Bin Three having genes of unknown clinical implication and Bin Two containing variants within genes that are clinically valid but not directly actionable.
From page 8...
... . to the NCHS Board of Scientific Counselors, which then called for wider input on how to proceed, not only with regard to NHANES but also because this has become an important issue for many population-based studies.


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