Review of the Formaldehyde Assessment in the National Toxicology Program 12th Report on Carcinogens (2014) / Chapter Skim
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Appendix E: Genotoxicity and Mutagenicity Summary Tables
Appendix E: Genotoxicity and Mutagenicity Summary Tables
Pages 207-232
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From page 207... ...
. The evidence is organized by cell-free systems; nonmammalian model organisms; mammalian in vitro systems in the rodent, primate, and human; mammalian in vivo systems showing portal-of-entry effects in the rodent, primate, and human; and mammalian in vivo systems showing systemic effects in the rodent, primate, and human.
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# M1G adduct has been postulated to be the result of secondary DNA damage from formaldehyde-associated oxidative stress. 1 The study was identified from the background document or the substance profile for formaldehyde in the National Toxicology Program 12th Report on Carcinogens (NTP 2010, 2011)
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19921 Huang and Hopkins 19931 Nonmammalian model organisms -- -- Mammalian in vitro Rodent -- -- Human -- -- Mammalian in vivo: Rodent -- -- portal-of-entry effects Primate -- -- Human -- -- Mammalian in vivo: Rodent -- -- systemic effects Primate -- -- Human -- -- 1 The study was identified from the background document or the substance profile for formaldehyde in the National Toxicology Program 12th Report on Carcinogens (NTP 2010, 2011)
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20084 Lu et al. 2010b4 Nonmammalian model organisms -- -- Mammalian in vitro Rodent Ross and Shipley 19801 Casanova et al.
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1996a, 20031 -- Lin et al. 20133 1 The study was identified from the background document or the substance profile for formaldehyde in the National Toxicology Program 12th Report on Carcinogens (NTP 2010, 2011)
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2010c3 portal-of-entry effects Primate -- -- Human -- --
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20123 Lin et al. 20133 1 The study was identified from the background document or the substance profile for formaldehyde in the National Toxicology Program 12th Report on Carcinogens (NTP 2010, 2011)
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2009b -- systemic effects Primate -- -- Human -- -- 1 The study was identified from the background document or the substance profile for formaldehyde in the National Toxicology Program 12th Report on Carcinogens (NTP 2010, 2011)
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19841 systemic effects Speit et al. 20091 Primate -- -- 1 Human Yager et al.
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2011b, 20122 1 The study was identified from the background document or the substance profile for formaldehyde in the National Toxicology Program 12th Report on Carcinogens (NTP 2010, 2011)
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20044 Gocke et al. 19811 systemic effects Gao et al.
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20133 Souza and Devi 20143 1 The study was identified from the background document or the substance profile for formaldehyde in the National Toxicology Program 12th Report on Carcinogens (NTP 2010, 2011)
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19921 -- portal-of-entry effects Primate -- -- Human -- -- Mammalian in vivo: Rodent Kitaeva et al. 19901 Fontignie-Houbrechts 19811 systemic effects Gomaa et al.
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20132 1 The study was identified from the background document or the substance profile for formaldehyde in the National Toxicology Program 12th Report on Carcinogens (NTP 2010, 2011)
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2002. Cytogenetic analysis of buccal cells from shoe-workers and pathology and anato my laboratory workers exposed to n-hexane, toluene, methyl ethyl ketone and formaldehyde.
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2011. Occupational exposure to formaldehyde: Genotoxic risk evaluation by comet assay and micronucleus test using human peripheral lymphocytes.
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2004. Low concentrations of formaldehyde induce DNA damage and delay DNA repair after UV irradiation in human skin cells.
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1986. Pathobiological effects of tobacco smoke-related aldehydes in cultured human bronchial epithelial cells.
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2013. Formaldehyde induces micronuclei in mouse erythropoietic cells and sup presses the expansion of human erythroid progenitor cells.
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2013. Occupational exposure to formaldehyde and genetic damage in the peripheral blood lymphocytes of plywood workers.
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2011. Determination of N2-hydroxymethyl-dG adducts in the nasal epithelium and bone marrow of nonhuman primates following 13CD2-formaldehyde inhalation exposure.
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2010a. Exposure of human nasal epithelial cells to formaldehyde does not lead to DNA damage in lymphocytes after co-cultivation.
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2014. Cytokinesis blocked micronucleus assay of peripheral lymphocytes revealing the genotoxic effect of formaldehyde exposure.
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2008b. Genotoxic effects of formaldehyde in the human lung cell line A549 and in primary human nasal epithelial cells.
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2013. Inhaled formaldehyde induces DNA-protein crosslinks and oxidative stress in bone marrow and other distant organs of exposed mice.
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2004b. Formaldehyde-induced DNA adducts as bi omarkers of in vitro human nasal epithelial cell exposure to formaldehyde.
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