Industrialization of Biology A Roadmap to Accelerate the Advanced Manufacturing of Chemicals (2015) / Chapter Skim
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5 What Is Success and How to Get There: Recommendations
5 What Is Success and How to Get There: Recommendations
Pages 101-110
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From page 101... ...
As outlined in Chapter 2, the production of chemicals through biological processes may help to reduce toxic by-products, to reduce greenhouse gas emissions, and to lower fossil fuel consumption in chemical production. The advanced manufacturing of chemicals through biology can help address global challenges related to energy, climate change, sustainable and more productive agriculture, and environmental sustainability.
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From page 102... ...
Subsequently, the UK government instituted the SBLC as a steering structure governance body to assess progress and update recommendations and shape priorities for future implementation of the roadmap in the UK. The SBLC provides a visible point for strategic coordination between the funding agencies, the research community, industry, government sponsors, and other stakeholders, including societal and ethical representatives.
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From page 103... ...
1 YEAR 2 Y EA RS 3 YEARS 4 YEARS 5 YEARS 6 YEAR S 7 YEARS 8 YEARS 9 YEARS 10 YEARS Carbon sources, including lignin, syngas, Carbon sources, including fermentable sugars methane, methanol, formate, and CO 2 , in Carbon sources, including fermentable sugars derived from soft derived from soft and hard cellulose, at $0.40 addition to fermentable sugars, at $0.30 cellulose, at $0.50 per kilogram per kilogram per kilogram Consistently and reliably achieve Develop tools to scale up fermenter productivity 10g/L-hr Operating process for an economically viable any bio-production process at steady state or following the bioreactor for gaseous feedstocks and/or products in 6 weeks growth in batch All bio-aqueous processes achieve 90% reuse of All bio-aqueous processes achieve 95% reuse All bio-aqueous processes achieve 80% reuse of process water process water of process water Integrated design toolchain for designing a Integrated design toolchain for designing Integrated design toolchain for designing a biomanufacturing biomanufacturing process at and below the an entire biomanufacturing process process at and below the level of an individual organism level of an individual biological reactor Ability to insert 1 megabase of wholly designed, synthetic DNA at an error rate of less than 1 in 100,000 base pairs, at cost $100, in 1 week Ability to design de novo enzymes with new catalytic activities with a high turnover rate Domestication of an additional 10 Domestication of 5 diverse industrially relevant microbial types and microbial types other than the ability to domesticate any microbial Achieve domestication of any established models type within 3 months microbial type within 6 weeks Suite of domesticated organisms and cell-free systems that can utilize diverse feedstocks and generate a range of products under various process conditions Ability to routinely measure nucleic acids, proteins, and metabolites targeted to characterize 50 or more high-priority, selectable model parameters for 2,000 strains and measure 1,000 or more parameters for 200 strains within 1 week at a cost no higher than the full cost of building those strains Ability to measure 50 or more high priority, selectable model parameters in vivo FEEDSTO CK S A ND FERM EN TATION DESIGN ORGANISM: ORGANISM: TEST AND PRE-PROCESS ING AND PROCESSIN G TOOLCHAIN PATHWAYS CHASSIS MEASUREMENT FIGURE 5-1 Technical roadmap to enable the industrialization of biology. 103 NOTE: A larger version of this roadmap can be found as a foldout at the end of this book.
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From page 104... ...
Since its founding, Sematech c has evolved to a global industry consortium, fully funded by its members. The Committee recommends that the relevant government agencies consider establishment of an ongoing roadmapping mechanism to provide direction to technology development, translation, and commercialization at scale.
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From page 105... ...
, Department of Energy, National Institutes of Health, National Insti tute of Standards and Technology, Department of Defense, and other relevant agencies should support the scientific research and foundational technologies required to advance and integrate the areas of feedstocks, organismal chassis and pathway development, fermentation, and processing as outlined in the roadmap goals. Supporting foundational research in these areas is critical to the growing commercial viability of biological processes in chemical manufacturing.
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From page 106... ...
NonTechnical Insights and Societal Concerns Economic Meeting the technical and scientific challenges involved in the industrialization of biology is necessary to realize the potential benefits, but ensuring that those benefits accrue rapidly and with maximum positive impact requires accurate and detailed information about the role of biobased production in the economy. The ability to predict economic trends, to assess economic impact, and to more completely understand the role of bio-based products in the economy will enable better decision making for all stakeholders involved in the industrialization of biology.
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From page 107... ...
Affording students the opportunity to experience industrial lab settings carries significant benefits to both students and future employers. The ability to plan for large-scale production and skill in developing significant scientific results into tangible, useful products are critical capabilities that the present and future chemical manufacturing demands.
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From page 108... ...
Recommendation: Science funding agencies and science policy offices should ensure outreach efforts that facilitate responsible innovation by enabling the extension of existing relevant regula tory practices, concordance across countries, and increased public engagement. Coordination across government bodies, combined with a commitment to transparency and public contribution and participation, will enable a governance framework that is at once navigable, perceived as legitimate, and achieves the societal goals critical to the public welfare.
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From page 109... ...
Concluding Remarks The industrialization of biology offers the prospect of addressing global as well as American national interests. The recommendations put forward are designed to facilitate the achievement of the roadmap goals and, ultimately, the challenge posed by the committee: to double the percentage of gross domestic product that comes from the bioeconomy by putting biological synthesis and engineering on par with chemical synthesis and engineering for chemical manufacturing.
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