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Beyond Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Redefining an Illness (2015) / Chapter Skim
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Appendix B: GRADE Grid Template
Pages 253-256

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From page 253...
... B GRADE Grid Template 253
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From page 254...
... Sleep (unrefreshing sleep, sleep disturbance/ dysfunction) Neurocognitive manifestations (mental fatigue, memory impairment, concentration difficulties, confusion)
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From page 255...
... Balance between desirable and undesirable effects of inclusion as a required or core symptom or symptom category Desirable consequence: The specific symptom or symptom category is present in a majority of ME/CFS patients, and its inclusion as a required symptom could prevent incorrect diagnoses of ME/CFS in those that do not have it. Undesirable consequence: The specific symptom or symptom category is not present in a majority of ME/CFS patients, and its requirement could thus exclude patients with ME/CFS from diagnosis.
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Key Terms

  • symptom category
  • specific symptom
  • undesirable effects
  • prevent incorrect
  • memory impairment

  • joint pain
  • strong recommendation
  • temperature extremes
  • concentration difficulties
  • unrefreshing sleep

  • neurocognitive manifestations
  • sweating episodes
  • core symptom
  • category desirable
  • incorrect diagnoses

  • neuroendocrine manifestations
  • thermostatic stability
  • exclude patients
  • mental fatigue
  • muscle pain

  • weak recommendation


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