Biographical Memoirs Volume 61 (1992) / Chapter Skim
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Dwight Joyce Ingle
Dwight Joyce Ingle
Pages 246-269
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From page 247... ...
The period of Dwight Tngle's active life was the time of rapid clevelopment in endocrine science, to which Tngle himself contributed greatly. His career incluclecI a series of statistically improbable successful ventures, chronicled in his autobiography, ~ Went to See the E1'ephant.~ The title comes from John Godfrey Saxe's story of "the six blind men of Tndostan," who describe an elephant according to the part of the animal they can touch with their hands, and Ingle clisplayed genuine modesty in choosing it, for, as he explains in the book's preface, "Science does involve looking at some specific properties of systems that are too big to get into perspective." With a simple and genuine modesty, he continues: 247
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He supported himself as a graduate student by working part time as a laboratory animal caretaker and by grading examination papers. The Great Depression was then under way in the Uniter!
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by questions on biology and physiology. After completing his graduate studies at the University of Minnesota Ingle moved to the Mayo Clinic, where he
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Ingle is responsible for at least three signal advances in endocrine science clevelopment of a bioassay for adrenal cortical hormones that facilitates! the purification of cortisone, documentation that the actrenal cortex and the pituitary gland interact by a negative feedback mechanism, and
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major contribution, namely in 1937 Ingle observed that the administration of adrenal cortical extracts or purifier} glucocorticoicts to intact rats causes atrophy of the acirenal glands. Actrenal atrophy couIcl be prevented by the simultaneous administration of pituitary extracts, ant!
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hormones, a train of thought that lee! to excursion into diverse aspects of physiology, including studies of the effects of adrenal steroids on carbohydrate physiology, investigations on the pathogenesis of hypotension (shock)
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Receiving consent, he dutifully reported that his graduate student had made an exciting cliscovery. To no one's surprise but the stuclent's, however, the next day's headlines react, "Professor X announces a major discovery." Professor X then became a noted participant in scientific seminars and a frequent guest lecturer on the subject of the stuclent's discovery.
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And so it was that the grandson announced his student's innovative study, and the next day the headlines read, "Professor Y announces spectacular new scientific results"with predictably favorable consequences to his career. This tale occupies eight pages of Tngle's autobiography, where he details several stages of the successful scientific career: appointments to journal editorships, membership on foundation and government grants committees, administrative posts.
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Sciences and was given the Modern Medicine Achievement Award. He was a member of Phi Beta Kappa, Sigma Xi, Alpha Omega Alpha, the American Association for the Advancement of Science, the American Physiological Society, the Endocrine Society President, ~ 959-60)
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Capacity of skeletal muscle in rats to maintain work output.
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Mayo Clinic 13: 733-34. A comparison of the amounts of cortin required to produce adrenal cortical atrophy in male and female rats.
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A comparison of the effects of 11-desoxycorticosterone acetate and 17-hydroxy-ll~lehydrocortico~erone in partially depancreatized rats.
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The effect of adrenocorticotrophic hormone on the urinary excretion of sodium, chloride, potassium, nitrogen and glucose in normal rats. Endocrinology 39:3242.
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Endocrinology 43:202-7. The effect of 11-desoxycorticosterone acetate upon the glycosuria of partially depancreatized rats.
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Work performance of adrenally insufficient rats given adrenal cortex extract by continuous intravenous injection.
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Work performance of adrenalectomized rats given cortisone and 17-hydroxycorticosterone by continuous intravenous injection.
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Purmalis. Effect of continuous injection of epinephrine upon the glycosuria of partially depancreatized rats.
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Flores. Comparative effects of muscle work and insulin upon plasma amino acids in eviscerated rats.
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Torralba. Effect of tumors on level of plasma amino acids on eviscerate rats.
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Effect of estrogen on liver glycogen in adrenalectomized rats.
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7:141-42. Exacerbation of glycosuria by partial hepatectomy in the partially depancreatized rat.
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Green, Inc. The need to investigate average biological differences among racial groups.
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