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Responsible Science Ensuring the Integrity of the Research Process: Volume II (1993) / Chapter Skim
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6 Congressional Activities Regarding Misconduct and Integrity in Science
Pages 117-125

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From page 117...
... Part B Selected Guidelines for the Conduct of Research
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From page 119...
... These Guidelines state general principles that NTH scientists are expected to follow in Heir research activities with regard to supervision of trainees, data management, publication practices, authorship, peer review and use of privileged information, and clinical investigations in order to promote the uniform application of the highest ethical standards to the conduct of all scientific research. It is the responsibility of each Laboratory or Branch Chief, and successive levels of supervisory individuals (especially Institute, Center, and Division Intramural Research Directors)
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From page 120...
... This supervised research represents not merely performance of tasks assigned by the supervisor but rather a process wherein the trainee takes on an increasingly independent role in the choice of research projects, development of hypotheses and the performance of the work. Indeed, if training is to prepare a young scientist for a successful career as a research investigator, it must be geared toward providing the trainee with the aforementioned skills and experiences.
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From page 121...
... Data Management Research data, including detailed experimental protocols, primary data from laboratory instruments, and procedures of reduction and analysis of primary data, are the essential components of scientific progress. Scientific integrity is inseparable from meticulous attention to the acquisition and maintenance of these research data.
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From page 122...
... Although appropriately considered the end point of a particular research project, publication is also the beginning of a process in which the scientific community at large can substantiate, correct and further develop a particular set of results. Timely publication of new and significant results is important for the progress of science, but fragmentary publication of the results of a scientific investigation or multiple publications of the same or similar data are inappropriate.
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From page 123...
... While mult~-authorsh~p Is not a problem in itself, it raises many issues such as criteria for inclusion as an author, ability of each author to evaluate and defend all aspects of a study, sequence of listing of authors, and separation of various experimental results to increase numbers of communications and authorship citations. To clarify some of these concerns, consideration should be given in interdisciplinary studies to preparing brief statements of the exact contribution of each author to the work described in each communication.
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From page 124...
... Material under review should not be used in any manner by the reviewer unless specifically permitted by the journal or reviewing organization and the author. Clinical Research Clinical research, for die purposes of these Guidelines, is defined as research performed on human subjects as part of human experimentation.
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From page 125...
... By virtue of its various sections governing background; patient eligibility and confidentiality; data to be collected; mechanism of data storage, retrieval, statistical analysis and reporting; and identification of the principal and associate investigators, the Clinical Research Protocol provides a highly codified mechanism covering most of the topics covered elsewhere in the Guidelines. The Clinical Research Protocol is generally widely circulated for comment, review and approval.
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Key Terms

  • research protocol
  • intramural research
  • clinical investigators
  • topics covered
  • scientific mentor

  • scientific method
  • privileged information
  • human experimentation
  • primary data
  • scientific colleagues

  • essential component
  • approved human
  • laboratory instruments
  • published experiments
  • coordinating responses

  • scientific evaluation
  • easily subject
  • medical management
  • interdisciplinary studies
  • primary experimental

  • process wherein
  • appropriately considered
  • material derived
  • perform laboratory
  • particularly critical

  • mechanism covering
  • primary scientific
  • proposed clinical
  • support structure
  • ethical standards


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