Skip to main content

Currently Skimming:

Appendix A: Executive Summary from 'Adverse Effects of Pertussis and Rubella Vaccines'
Pages 309-317

The Chapter Skim interface presents what we've algorithmically identified as the most significant single chunk of text within every page in the chapter.
Select key terms on the right to highlight them within pages of the chapter.


From page 309...
... APPENDIX A Executive Summary from Adverse Effects of Pertussis and Rubella Vaccines Reprinted from Institute of Medicine, Adverse Effects of Pertussis and Rubella Vaccines, National Academy Press, 1991.
From page 310...
... to conduct a thorough review of the evidence pertaining to a set of serious adverse events and immunization with pertussis or rubella vaccine. The request to IOM originated in the 1986 National Childhood Vaccine Injury Act (Public Law 99-660)
From page 311...
... Pertussis and Rubella Vaccines: A Brief Chronology.) The following three sections of this summary briefly review the methods used by the committee to evaluate the evidence relating the 20 adverse events to pertussis or rubella vaccine, the evidence considered and the conclusions reached for each adverse event, and the research directions recommended by the committee.
From page 312...
... These and other features raise a number of difficulties both in the investigation and in the evaluation of the resulting evidence. The committee considered causal questions of three kinds in connection with adverse events that have been reported to occur after administration of pertussis or rubella vaccine.
From page 313...
... . As shown in Table 1-2, the committee found: · no evidence bearing on a causal relation between DPT vaccine and autism; · insufficient evidence to indicate a causal relation between DPT vaccine and aseptic meningitis, chronic necrologic damage, erythema multiforme or other rash, Guillain-Barre syndrome, hemolytic anemia, juvenile diabetes, learning disabilities and attention deficit disorder, peripheral mononeurop
From page 316...
... Evidence insufficient to indicate a causal relationd 3. Evidence does not indicate a causal relatione Autism Aseptic meningitis Chronic necrologic damage Erythema multiforme or other rash Guillain-Barre syndrome Hemolytic anemia Juvenile diabetes Learning disabilities and attention-deficit disorder Peripheral mononeuropathy Thrombocytopenia Infantile spasms Hypsarrythmia Reye syndrome Sudden infant death syndrome Radiculoneuritis and other neuropathies Thrombocytopenic purpura 4.
From page 317...
... ~ RESEARCH NEEDS In the course of its review, the committee encountered many gaps and limitations in knowledge bearing directly and indirectly on the safety of vaccines. These include inadequate understanding of the biologic mechanisms underlying adverse events following natural infection or immunization, insufficient or inconsistent information from case reports and case series, inadequate size or length of follow-up of many population-based epidemiologic studies, and limited capacity of existing surveillance systems of vaccine injury to provide persuasive evidence of causation.


This material may be derived from roughly machine-read images, and so is provided only to facilitate research.
More information on Chapter Skim is available.