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Appendix C: Technical Recommendations for Department of Pesticide Regulation Risk Assessments
Pages 50-54

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From page 50...
... DEFINITION OF ADVERSE EFFECTS Sound scientific practice for hazard identification involves a determination of whether an observed effect is adverse. The US Environmental Protection Agency (EPA)
From page 51...
... . Typically, EPA does not perform such extrapolations for fumigant risk assessments when adequate inhalation data are available but prefers to use an inhalation-specific approach that estimates a human-equivalent concentration.
From page 52...
... DPR's guidance does not appear to allow estimation of a human-equivalent concentration and presents default values of 100.5 for both the pharmacokinetic and pharmacodynamic portions of the uncertainty factor. The committee recommends that DPR's guidance be updated to allow estimation of human-equivalent concentrations from animal data and relevant adjustment of the pharmacokinetic portion of the uncertainty factor applied for interspecies differences.
From page 53...
... EPA/100/R 14/002F. Risk Assessment Forum, Office of the Science Advisor, US Environmental Protection Agency, Washington, DC.
From page 54...
... . Air Toxicology and Epi demiology Branch, Office of Environmental Health Hazard Assessment, California Environmental Protection Agency.

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