Rapid Medical Countermeasure Response to Infectious Diseases Enabling Sustainable Capabilities Through Ongoing Public- and Private-Sector Partnerships: Workshop Summary (2016) / Chapter Skim
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2 A Wake-Up Call: The 2014 Ebola Outbreak Response
2 A Wake-Up Call: The 2014 Ebola Outbreak Response
Pages 9-16
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From page 9... ...
This chapter highlights what speakers described as critical gaps in preparedness and response across sectors. The multidisciplinary gaps include appreciating the threat level, achieving science preparedness, conducting disease surveillance, MCM development, relationship building, and accountability.
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From page 10... ...
Most developing countries have fragile or fragmented health care systems, and there is not an appreciation of the benefits of public health, Farrar said. Health ministers in many countries are in relatively weak positions within executive body cabinets and are not empowered to be advocates for change within governments.
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In a step toward global science preparedness, new vaccines and therapies in development are being tested in both established research networks and new research networks in West Africa, many of which are being led locally by African partners. Despite these efforts to become more scientifically prepared, she lamented, there was no standardized case report form either for patients in West Africa or for medically evacuated patients.
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From page 12... ...
Gaps in Data Collection and Surveillance In West Africa, efforts to collect and transmit data were very limited until late in the epidemic because of the challenges of working in the "hot zone" itself, and because the humanitarian workers in those countries believe their primary mission to be caring for the very sick, not to perform scientific data collection and analysis, Assistant Secretary Lurie commented. Science preparedness1 was also hampered, she said, by global disagreements about study design, ethical standards, insufficient infrastructure to conduct clinical trials of any kind, and a perceived lack of urgency regarding how to move forward with experimental treatment therapies or potential vaccines.
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From page 13... ...
Gaps in Sustainable MCM Development Elements of sustainable MCM development include partner commitment, financial models to ensure long-term resources, infrastructure, trust, advocacy by and for the beneficiaries of MCM development, and building on existing strengths and progress. Scientifically, Lurie said, there has been tremendous progress, not just with new vaccines and therapies but also platforms for rapid development of diagnostics and for product manufacturing.
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From page 14... ...
They do not come from flying in with resources during a crisis and flying out when the event is over, he said. Gaps in Accountability The health infrastructure in developing countries, particularly where Ebola has recently emerged, is almost nonexistent despite decades of investment in health system strengthening by bilateral donors and national governments, said Rajeev Venkayya, president of the Global Vaccine Business Unit at Takeda Pharmaceuticals.
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From page 15... ...
This coordinating, overarching role, allowing the departments and agencies to focus on and execute their roles and responsibilities without overlap or duplication, could be very helpful.
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